From the *Keck School of Medicine of the University of Southern California; and †Department of Radiology, LAC+USC Medical Center, Los Angeles, CA.
Clin Nucl Med. 2014 Jul;39(7):e355-8. doi: 10.1097/RLU.0000000000000458.
Diastolic dysfunction is commonly associated with heart failure with preserved systolic function. Diastolic abnormality includes progressively impaired left ventricle (LV) relaxation, followed by pseudonormal mitral inflow pattern with Valsalva enhancement, and finally restrictive LV filling. Diastolic dysfunction may lead to left atrial dilatation with consequent atrial fibrillation. Gated myocardial perfusion SPECT evaluates systolic function with LV volumes and ejection fraction, but its ability to identify diastolic dysfunction is not typically considered. We correlate 16-phase gated SPECT time-volume curves with echo Doppler early/late diastolic flow ratios for diastolic dysfunction.
舒张功能障碍通常与收缩功能保留的心力衰竭相关。舒张异常包括左心室（LV）松弛逐渐受损，随后出现瓦尔萨尔瓦增强的假性正常二尖瓣流入模式，最后是限制性 LV 充盈。舒张功能障碍可导致左心房扩张，进而导致心房颤动。门控心肌灌注 SPECT 通过 LV 容积和射血分数评估收缩功能，但通常不考虑其识别舒张功能障碍的能力。我们将 16 相位门控 SPECT 时-容积曲线与超声心动图多普勒早期/晚期舒张血流比值相关联，以评估舒张功能障碍。
