Korkmaz Ayse Nurdan, Caliskan Billur, Erdem Fatma
Department of Nuclear Medicine, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
Department of Cardiology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
World J Nucl Med. 2017 Jul-Sep;16(3):206-211. doi: 10.4103/1450-1147.207278.
Early identification of diastolic dysfunction of patients with diabetes is important in preventing cardiac events. In this study, we aimed to show that both myocardial perfusion and diastolic function parameters can be evaluated in diabetic patients with possible silent cardiac symptoms using gated single-photon emission computed tomography (G-SPECT). We examined eighty patients: Forty with and forty without diabetes. The patients were compared in terms of systolic and diastolic parameters obtained using G-SPECT. Tc-sestamibi was used to obtain 8-frame images in each cardiac cycle, with calculation of the left ventricular ejection fraction (LVEF), peak filling rate (PFR), mean filling rate during the first third of diastolic time (MFR/3), and time to peak filling (TTPF) using the QGS software. G-SPECT results were compared in forty diabetic and forty nondiabetic patients of similar age and sex. Of the diastolic function parameters, PFR was found to be lower in patients with than without diabetes (2.31 ± 0.68 vs. 2.76 ± 0.68, respectively; = 0.004). The TTPF and MFR/3 in both groups were similar. PFR was negatively correlated with end-diastolic volume and end-systolic volume (ESV) and positively correlated with LVEF. This correlation was stronger in patients with diabetes. The diastolic parameter PFR, obtained using G-SPECT, was significantly lower in patients with than without diabetes. We believe that these parameters should be noted for the early diagnosis or prevention of heart disease in patients with a risk of diastolic dysfunction.
早期识别糖尿病患者的舒张功能障碍对于预防心脏事件很重要。在本研究中，我们旨在表明，使用门控单光子发射计算机断层扫描（G-SPECT）可以在有潜在无症状心脏症状的糖尿病患者中评估心肌灌注和舒张功能参数。我们检查了80名患者：40名患有糖尿病，40名未患糖尿病。对患者使用G-SPECT获得的收缩和舒张参数进行了比较。使用锝- sestamibi在每个心动周期获取8帧图像，并使用QGS软件计算左心室射血分数（LVEF）、峰值充盈率（PFR）、舒张期前三分之一期间的平均充盈率（MFR/3）和达到峰值充盈的时间（TTPF）。比较了40名年龄和性别相似的糖尿病患者和40名非糖尿病患者的G-SPECT结果。在舒张功能参数中，发现糖尿病患者的PFR低于非糖尿病患者（分别为2.31±0.68和2.76±0.68；P = 0.004）。两组的TTPF和MFR/3相似。PFR与舒张末期容积和收缩末期容积（ESV）呈负相关，与LVEF呈正相关。这种相关性在糖尿病患者中更强。使用G-SPECT获得的舒张参数PFR在糖尿病患者中明显低于非糖尿病患者。我们认为，对于有舒张功能障碍风险的患者，这些参数应被注意用于早期诊断或预防心脏病。
