Saldarriaga-Cantillo Alejandra, Bravo Luis Eduardo, Londoño Oscar, García Luz Stella, Collazos Paola
Cancer Registry of Cali. Departament of Pathology. Universidad del Valle, Cali, Colombia. E-mail:
Secretaria de Salud Publica Municipal de Cali.
Colomb Med (Cali). 2012 Dec 30;43(4):273-80. eCollection 2012 Oct.
The Kaposi's sarcoma (KS) incidence has markedly changed in the general population since the onset of the AIDS epidemic in the eighties and after the introduction of the Highly Active Antiretroviral Therapy (HAART) in the nineties.
To investigate incidence rate trends for Kaposi's sarcoma before and during the (HIV/AIDS) epidemic in Cali, Colombia.
Exploratory ecological study that included all Kaposi's sarcoma cases identified by the Cali Cancer Registry from 1962-2007, and 12,887 cases of HIV/AIDS recorded in the Municipal Health Secretariat of Cali between 1986 and 2010. The joinpoint regression model was used to conduct the incidence rate analyses between the years 1962 and 2010.
A total of 349 KS cases were identified during the study period. Only 5.3% of the cases (n=20) were diagnosed in the pre-epidemic era (1963-1987), of these, 35% were women, and 90% of the tumors were located on the skin. In contrast, 94.7% of KS cases (n=329) were discovered after the emergence of HIV-AIDS. There was a significant decrease in the proportion of women (10.9%, p <0.001) and an increase in the frequency of tumors with an extra-cutaneous location (19.1%, p <0.01) compared to those cases diagnosed in the pre-epidemic era. Notification rates of HIV/AIDS have decreased since 2002 in both genders but KS incidence rates have decreased since 2004 in men only.
The downward trend in the incidence of these diseases may be associated with factors that prevent the transmission of HIV infection or limit the spread of HIV in the community. Cancer registries represent a resource for timely, population-based surveil-lance of HIV-associated malignancies in Cali, Colombia.
自20世纪80年代艾滋病流行开始以及90年代引入高效抗逆转录病毒疗法（HAART）以来，卡波西肉瘤（KS）在普通人群中的发病率发生了显著变化。
调查哥伦比亚卡利市在（艾滋病毒/艾滋病）流行之前及期间卡波西肉瘤的发病率趋势。
开展探索性生态研究，纳入了卡利癌症登记处1962年至2007年确诊的所有卡波西肉瘤病例，以及卡利市卫生秘书处1986年至2010年记录的12887例艾滋病毒/艾滋病病例。采用连接点回归模型对1962年至2010年期间的发病率进行分析。
研究期间共确诊349例卡波西肉瘤病例。仅5.3%的病例（n = 20）在流行前时期（1963年至1987年）被诊断，其中35%为女性，90%的肿瘤位于皮肤。相比之下，94.7%的卡波西肉瘤病例（n = 329）在艾滋病毒/艾滋病出现后被发现。与流行前时期诊断的病例相比，女性比例显著下降（10.9%，p < 0.001），皮肤外部位肿瘤的频率增加（19.1%，p < 0.01）。自2002年以来，男女艾滋病毒/艾滋病报告率均有所下降，但仅男性的卡波西肉瘤发病率自2004年以来有所下降。
这些疾病发病率的下降趋势可能与预防艾滋病毒感染传播或限制艾滋病毒在社区传播的因素有关。癌症登记处是对哥伦比亚卡利市艾滋病毒相关恶性肿瘤进行及时、基于人群监测的一种资源。
