San Francisco Department of Public Health, AIDS Office, USA.
AIDS. 2011 Feb 20;25(4):463-71. doi: 10.1097/QAD.0b013e32834344e6.
To assess the impact of HAART use on AIDS-defining Kaposi's sarcoma and non-Hodgkin lymphoma (NHL) among adults with AIDS.
Registry linkage study.
Adults diagnosed with AIDS from 1990 to 2000 in the San Francisco AIDS case registry were matched with cancer cases diagnosed from 1985 to 2002 in the California Cancer Registry. Multivariate Cox proportional hazard models were used to evaluate the risk and survival of AIDS-related Kaposi's sarcoma, systemic NHL, and primary central nervous system (CNS) lymphoma.
Of the 14 183 adults with AIDS, 3028 were diagnosed with Kaposi's sarcoma, 776 with systemic NHL, and 254 with CNS NHL. After adjustment for potential confounders, more recent calendar period and use of HAART were significantly associated with a decreased risk of Kaposi's sarcoma, whereas HAART use but not calendar period was significantly associated with systemic and CNS NHL. In adjusted analysis of Kaposi's sarcoma survival time, there was strong evidence of a reduced risk of death associated with HAART use and more recent calendar period. In contrast, in adjusted analyses of systemic NHL survival time, HAART use was not associated with improved survival time; however, calendar period was associated with longer survival. In adjusted analysis of CNS NHL survival time, only cancer treatment was associated with a longer survival time.
After controlling for calendar period and other confounders, use of HAART decreased the risk of Kaposi's sarcoma, systemic NHL, and CNS NHL. Use of HAART also increased Kaposi's sarcoma survival time but not NHL survival time.
评估高效抗逆转录病毒疗法（HAART）的使用对艾滋病患者中艾滋病定义性卡波西肉瘤和非霍奇金淋巴瘤（NHL）的影响。
登记关联研究。
从 1990 年至 2000 年，旧金山艾滋病病例登记处诊断为艾滋病的成年人与 1985 年至 2002 年加利福尼亚癌症登记处诊断为癌症的病例相匹配。采用多变量 Cox 比例风险模型评估艾滋病相关卡波西肉瘤、系统性 NHL 和原发性中枢神经系统（CNS）淋巴瘤的风险和生存情况。
在 14183 名艾滋病成年人中，3028 人诊断为卡波西肉瘤，776 人诊断为系统性 NHL，254 人诊断为 CNS NHL。在调整了潜在混杂因素后，最近的日历时间和 HAART 的使用与卡波西肉瘤风险降低显著相关，而 HAART 的使用而不是日历时间与系统性和 CNS NHL 显著相关。在调整后的卡波西肉瘤生存时间分析中，HAART 的使用与死亡风险降低有很强的关联，而最近的日历时间也有一定的关联。相反，在调整后的系统性 NHL 生存时间分析中，HAART 的使用与生存时间的改善没有关联；然而，日历时间与更长的生存时间相关。在调整后的 CNS NHL 生存时间分析中，只有癌症治疗与更长的生存时间相关。
在控制了日历时间和其他混杂因素后，HAART 的使用降低了卡波西肉瘤、系统性 NHL 和 CNS NHL 的风险。HAART 的使用还增加了卡波西肉瘤的生存时间，但没有增加 NHL 的生存时间。
