与剥脱性青光眼相关的基因多态性也与原发性开角型青光眼的风险相关。
Genetic polymorphism related to exfoliative glaucoma is also associated with primary open-angle glaucoma risk.
作者信息
Zanon-Moreno Vicente, Zanon-Moreno Laura, Ortega-Azorin Carolina, Asensio-Marquez Eva M, Garcia-Medina Jose Javier, Sanz Pedro, Pinazo-Duran Maria D, Ordovás Jose M, Corella Dolores
机构信息
Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, Spain; Ophthalmology Research Unit 'Santiago Grisolia', Valencia, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain.
出版信息
Clin Exp Ophthalmol. 2015 Jan-Feb;43(1):26-30. doi: 10.1111/ceo.12367. Epub 2014 Aug 7.
BACKGROUND
To investigate the possible association of the rs2165241 polymorphism (C > T) in LOXL1 gene with the risk of primary open-angle glaucoma in a Mediterranean population.
METHODS
The analysis of genetic polymorphisms was performed by standard TaqMan allelic discrimination technique, using a 7900HT Sequence Detection System (Applied Biosystems).
RESULTS
In a recessive genetic model, the T allele of the rs2165241 polymorphism was significantly associated with the risk of primary open-angle glaucoma (TT vs. CC: odds ratios = 2.19, 95% confidence interval = [1.33-3.62]). After multivariate logistic regression model adjusted by age and weight, the magnitude of the association decreased but remained statistically significant (TT vs. CC: odds ratios = 2.07, 95% confidence interval = [1.20-3.57]).
CONCLUSION
This polymorphism seems to be associated with high risk for primary open-angle glaucoma in a Mediterranean population.
背景
研究地中海人群中赖氨酰氧化酶1（LOXL1）基因rs2165241多态性（C>T）与原发性开角型青光眼风险之间的可能关联。
方法
采用标准TaqMan等位基因鉴别技术，使用7900HT序列检测系统（应用生物系统公司）进行基因多态性分析。
结果
在隐性遗传模型中，rs2165241多态性的T等位基因与原发性开角型青光眼风险显著相关（TT与CC相比：比值比=2.19，95%置信区间=[1.33 - 3.62]）。在经年龄和体重调整的多因素逻辑回归模型中，关联强度降低但仍具有统计学意义（TT与CC相比：比值比=2.07，95%置信区间=[1.20 - 3.57]）。
结论
这种多态性似乎与地中海人群原发性开角型青光眼的高风险相关。
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