Ren Zhengbing, Li Mingna, Liu Ruiping, Wang Yong, Gu Haiyong
Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University , Zhenjiang , China .
Biomarkers. 2014 Aug;19(5):411-6. doi: 10.3109/1354750X.2014.924158. Epub 2014 Jun 4.
Gastric cardia adenocarcinoma (GCA) is one of the most common malignant tumors. In addition to environmental risk factors, genetic factors might play an important role in GCA carcinogenesis. To evaluate the association between polymorphisms in the interleukin 17A (IL17A) gene on the development of GCA, we conducted a hospital-based case-control study. A total of 243 GCA cases and 476 controls were recruited and their genotypes were determined using a custom-by-design 48-Plex SNPscan™ Kit. IL17A rs3819024 A > G polymorphism was found to be associated with the increased risk of GCA. When the IL17A rs3819024 AA homozygote genotype was used as the reference group, the AG genotype was associated with a significantly increased risk of GCA (AG versus AA: adjusted OR = 1.53, 95% CI = 1.05-2.23, p = 0.026). However, there was no significant association between five other SNPs and GCA. Stratified analyses indicated that a significantly increased risk of GCA associated with the IL17A rs3819024 A > G polymorphism was evident among male patients, patients who drank alcohol or those who never smoked. These findings indicated that functional polymorphism IL17A rs3819024 A > G might contribute to GCA susceptibility. Future larger studies with more rigorous study designs are required to confirm the current findings.
贲门腺癌（GCA）是最常见的恶性肿瘤之一。除环境风险因素外，遗传因素可能在GCA致癌过程中起重要作用。为评估白细胞介素17A（IL17A）基因多态性与GCA发生之间的关联，我们开展了一项基于医院的病例对照研究。共招募了243例GCA病例和476例对照，并使用定制的48重SNPscan™试剂盒确定其基因型。发现IL17A rs3819024 A>G多态性与GCA风险增加有关。以IL17A rs3819024 AA纯合子基因型作为参照组时，AG基因型与GCA风险显著增加相关（AG与AA相比：调整后的OR=1.53，95%CI=1.05-2.23，p=0.026）。然而，其他五个单核苷酸多态性（SNP）与GCA之间无显著关联。分层分析表明，在男性患者、饮酒患者或从不吸烟的患者中，IL17A rs3819024 A>G多态性与GCA风险显著增加相关。这些发现表明，功能性多态性IL17A rs3819024 A>G可能导致GCA易感性。需要未来采用更严谨研究设计的更大规模研究来证实当前的发现。
