Interleukin 15 receptor alpha rs2228059 A > C polymorphism decreased risk of gastric cardiac adenocarcinoma in a Chinese population.

Gastric cardiac adenocarcinoma (GCA) is one of the common malignant tumors in the world and has a high incidence in China. Both environmental risk factors and genetic factors might play an essential role in the GCA carcinogenesis. We performed a hospital-based case-control study to evaluate the genetic effects of interleukin 15 (IL15) and IL15 receptor alpha (IL15RA) functional single nucleotide polymorphisms (SNPs) on the pathogenesis of GCA. A total of 243 GCA cases and 476 controls were enrolled in this study. The genotypes were determined using a custom-by-design 48-Plex SNPscan(TM) Kit. When the IL15RA rs2228059 AA homozygote genotype was used as the reference group, the CC genotype was correlated with a significantly decreased risk for GCA (CC vs. AA: adjusted OR = 0.61, 95 % CI = 0.37-0.98, p = 0.042). Our results revealed that functional variant IL15RA rs2228059 A > C might attenuate individual's risk of GCA. However, there was no significant association between the other five IL15 SNPs and GCA susceptibility. This present study demonstrated that IL15RA rs2228059 A > C polymorphism might modify GCA susceptibility. The results were based on a limited sample size; future larger studies with more rigorous designs are warranted to validate our findings.