Micoulaud-Franchi Jean-Arthur, Hetrick William P, Aramaki Mitsuko, Bolbecker Amanda, Boyer Laurent, Ystad Sølvi, Kronland-Martinet Richard, Richieri Raphaëlle, Faget Catherine, Faugere Mélanie, El-Kaim Alexandre, Cermolacce Michel, Lancon Christophe, Vion-Dury Jean
Pôle de Psychiatrie "Solaris", Centre Hospitalier Universitaire de Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France; Unité de Neurophysiologie et Psychophysiologie, Pôle de Psychiatrie Universitaire, CHU Sainte-Marguerite, 270 Bd Sainte-Marguerite, 13009 Marseille, France; Laboratoire de Neurosciences Cognitives (LNC), UMR CNRS 7291, 31 Aix-Marseille Université, Site St Charles, 3 place Victor Hugo, 13331 Marseille Cedex 3, France.
Department of Psychological and Brain Sciences, Indiana University, 1101 East Tenth Street, Bloomington, IN 47405, United States; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States; Larue D. Carter Memorial Hospital, Indianapolis, IN, United States.
Schizophr Res. 2014 Aug;157(1-3):157-62. doi: 10.1016/j.schres.2014.05.013. Epub 2014 Jun 2.
P50 amplitude changes in dual click conditioning-testing procedure might be a neurophysiological marker of deficient sensory gating in schizophrenia. However, the relationship between abnormalities in the neurophysiological and phenomenological dimensions of sensory gating in schizophrenia remains unclear. The aim of the present study was to determine if patients with low P50-suppression (below 50%) report more perceptual anomalies.
Three groups were compared: twenty-nine schizophrenia patients with high P50-suppression (above 50% amplitude suppression), twenty-three schizophrenia patients with low P50-suppression (below 50%) and twenty-six healthy subjects. The Sensory Gating Inventory (SGI), a four-factor self-report questionnaire, was used to measure perceptual anomalies related to sensory gating. A comparison of demographic and clinical data was also carried out.
Patients with low P50-suppression presented: i) significantly higher scores on the SGI (for the overall SGI score and for each of the 4 factors) and ii) significantly larger P50 amplitude at the second click, than both patients with high P50-suppression and healthy subjects. There were no group differences in the most of demographic and clinical data.
The finding offers support for conceptual models wherein abnormal neurophysiologic responses to repetitive stimuli give rise to clinically relevant perceptions of being inundated and overwhelmed by external sensory stimuli. Further studies are needed to explore the contributions of clinical symptoms, medication and neuropsychological functions to the relationship between P50-suppression and the SGI, and the role of sensory "gating in" versus "gating out".
双声点击条件测试程序中P50波幅变化可能是精神分裂症感觉门控缺陷的神经生理学标志物。然而，精神分裂症感觉门控的神经生理学维度与现象学维度异常之间的关系仍不清楚。本研究的目的是确定P50抑制率低（低于50%）的患者是否报告更多的感知异常。
比较三组：29例P50抑制率高（波幅抑制高于50%）的精神分裂症患者、23例P50抑制率低（低于50%）的精神分裂症患者和26名健康受试者。使用感觉门控量表（SGI），这是一份四因素自我报告问卷，来测量与感觉门控相关的感知异常。还对人口统计学和临床数据进行了比较。
P50抑制率低的患者表现为：i）SGI得分显著更高（总体SGI得分以及4个因素中的每一个因素），ii）与P50抑制率高的患者和健康受试者相比，第二次点击时P50波幅显著更大。在大多数人口统计学和临床数据方面，各组之间没有差异。
这一发现为概念模型提供了支持，在该模型中，对重复刺激的异常神经生理反应会导致临床上出现被外部感觉刺激淹没和压倒的相关感知。需要进一步研究来探讨临床症状、药物治疗和神经心理功能对P50抑制与SGI之间关系的影响，以及感觉“传入门控”与“传出门控”的作用。
