Isaacs David A, Xue Andrew, Conley Alexander C, Key Alexandra P
Department of Neurology, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN 37232, USA.
Department of Neuroscience, Vanderbilt University, 2201 West End Ave, Nashville, TN 37235, USA.
Clin Neurophysiol. 2024 Dec;168:72-82. doi: 10.1016/j.clinph.2024.10.006. Epub 2024 Oct 19.
Over 80% of adults with chronic tic disorder (CTD) experience sensory over-responsivity (SOR), defined as heightened awareness of and/or behavioral reactivity to commonplace environmental stimuli. One potential mechanism underpinning SOR is sensory gating impairment. Sensory gating is the physiologic process whereby redundant stimuli are filtered out in early perceptual stages. In this study, we compared sensory gating between neurotypical and CTD adults and determined if gating indices associated with SOR.
Neurotypical (n = 31) and CTD adults (n = 26) completed a clinical assessment, including two SOR measures (Sensory Gating Inventory, SGI; Sensory Perception Quotient, SPQ), and an auditory gating paradigm while monitored on EEG.
CTD adults exhibited greater SOR. Neurotypical and CTD adults did not differ in P50, N100, or P200 gating ratios. In regression analyses, N100 gating ratio was significantly associated with SGI score; the magnitude of this association was greater for neurotypical than CTD adults. No other significant associations emerged between gating ratios and SOR measures.
Findings do not support sensory gating impairment as a mechanism underpinning SOR in CTD. The relationship between N100 gating and SOR warrants further investigation.
This is the first study to examine auditory gating in individuals with CTD.
超过80%的慢性抽动障碍（CTD）成人经历感觉过度反应（SOR），其定义为对常见环境刺激的意识增强和/或行为反应性增强。支持SOR的一种潜在机制是感觉门控受损。感觉门控是一种生理过程，通过该过程冗余刺激在早期感知阶段被过滤掉。在本研究中，我们比较了神经典型成人和CTD成人之间的感觉门控，并确定门控指数是否与SOR相关。
神经典型成人（n = 31）和CTD成人（n = 26）完成了一项临床评估，包括两项SOR测量（感觉门控量表，SGI；感觉知觉商数，SPQ），以及在脑电图监测下的听觉门控范式。
CTD成人表现出更高的SOR。神经典型成人和CTD成人在P50、N100或P200门控比率上没有差异。在回归分析中，N100门控比率与SGI得分显著相关；这种关联的强度在神经典型成人中比CTD成人更大。门控比率与SOR测量之间没有出现其他显著关联。
研究结果不支持感觉门控受损是CTD中SOR的一种潜在机制。N100门控与SOR之间的关系值得进一步研究。
这是第一项研究CTD个体听觉门控情况的研究。
