Wieczorek H, Oberdörster G
Pol J Occup Med. 1989;2(3):248-60.
Lung clearance, tissue distribution and elimination of manganese was studied in male Long-Evans rats. Animals were exposed for 1 hr by nose only to 54MnCl2 in concentrations of 54MnCl2: 129 mg Mn/m3 and 2.93 micrograms Mn/m3. Activity of 54Mn in lung, brain, liver, kidney, stomach, large and small intestine, blood, urine and feces was determined on days 0, 1, 2, 7, 14, 28, 60 and 121. Inhaled 54MnCl2 was cleared from the lung of rates biexponentially; at the high concentration, the fast and the slow phases had half-times, of 0.2 and 10.5 days, respectively. At the low concentration, the rapid and the slow phases had half times of 1.8 and 12.7 days, respectively. Relative uptake into the brain was independent of inhaled concentration and did not exceed 1 percent of lung deposition on day 0. After the high concentration, liver and kidney Mn levels peaked immediately at the end of exposure and decreased rapidly during the first two days. After the low exposure, liver and kidney accumulation was maximal on day 2 and then organ levels decreased like those of the high exposure group. Relative Mn content in the GI tract was similar after high and low exposure, except for the large intestine where much higher levels were measured in the early phase after inhalation of the high concentration. These data show that concentration of inhaled Mn has a significant influence on its organ distribution and elimination rates.
在雄性Long-Evans大鼠中研究了锰的肺清除、组织分布和消除情况。动物仅通过鼻腔暴露1小时，接触浓度分别为129 mg Mn/m³和2.93 μg Mn/m³的54MnCl₂。在第0、1、2、7、14、28、60和121天测定肺、脑、肝、肾、胃、大肠和小肠、血液、尿液和粪便中的54Mn活性。吸入的54MnCl₂从大鼠肺部以双指数方式清除；在高浓度下，快速相和缓慢相的半衰期分别为0.2天和10.5天。在低浓度下，快速相和缓慢相的半衰期分别为1.8天和12.7天。脑内的相对摄取与吸入浓度无关，在第0天不超过肺沉积量的1%。高浓度暴露后，肝和肾中的锰水平在暴露结束时立即达到峰值，并在头两天迅速下降。低浓度暴露后，肝和肾中的蓄积在第2天达到最大，然后器官中的水平像高浓度暴露组一样下降。高、低暴露后胃肠道中的相对锰含量相似，但在吸入高浓度后的早期，大肠中的锰含量要高得多。这些数据表明，吸入锰的浓度对其器官分布和消除速率有显著影响。
