Isaac Jennifer, Murugan Malavika
Neuroscience Graduate Program, Emory University, Atlanta, GA 30322, USA; Department of Biology, Emory University, Atlanta, GA 30322, USA.
Neuroscience Graduate Program, Emory University, Atlanta, GA 30322, USA; Department of Biology, Emory University, Atlanta, GA 30322, USA.
Trends Neurosci. 2024 Dec;47(12):1041-1054. doi: 10.1016/j.tins.2024.10.004. Epub 2024 Nov 11.
Across species, social behaviors are shaped and maintained through positive reinforcement of affiliative social interactions. As with nonsocial rewards, the reinforcing properties of social interactions have been shown to involve interplay between various brain regions and the mesolimbic reward system. In this review, we summarize findings from rodent research on the neural circuits that encode and mediate different components of social reward-seeking behavior. We explore methods to parse and study social reward-related behaviors using available behavioral paradigms. We also compare the neural mechanisms that support social versus nonsocial reward-seeking. Finally, we discuss how internal state and neuromodulatory systems affect reward-seeking behavior and the neural circuits that underlie social reward.
在不同物种中，社会行为通过对亲和性社会互动的正强化得以塑造和维持。与非社会奖励一样，社会互动的强化特性已被证明涉及多个脑区与中脑边缘奖赏系统之间的相互作用。在这篇综述中，我们总结了啮齿动物研究中关于编码和介导社会奖赏寻求行为不同组成部分的神经回路的研究结果。我们探索了利用现有行为范式解析和研究与社会奖赏相关行为的方法。我们还比较了支持社会奖赏寻求与非社会奖赏寻求的神经机制。最后，我们讨论了内部状态和神经调节系统如何影响奖赏寻求行为以及构成社会奖赏基础的神经回路。
