Department of Surgery, Austin Health, Melbourne, VIC, Australia; Department of Urology, University of Melbourne, Austin Health, Melbourne, VIC, Australia.
BJU Int. 2014 Mar;113 Suppl 2:40-7. doi: 10.1111/bju.12594.
Gastrin-releasing peptide (GRP) acts as an important regulatory peptide in several normal physiological processes and as a growth factor in certain cancers. In this review we provide a comprehensive overview of the current state of knowledge of GRP in urological tissues under both normal and cancerous conditions. GRP and its receptor, GRP-R, are expressed in the normal kidney and renal cancers. GRP can stimulate the growth of renal cancer cells. GRP and GRP-R are expressed in prostate cancer and GRP can stimulate the growth of prostate cancer cell lines. Importantly, GRP is a key neuroendocrine peptide, which may be involved in the progression of advanced prostate cancer and in the neuroendocrine differentiation of prostate cancer. Recent animal studies have shown that GRP and GRP-R are an integral part of male sexual function and play a crucial role in spinal control of erections and ejaculation.
胃泌素释放肽（GRP）在几种正常生理过程中作为一种重要的调节肽，在某些癌症中作为生长因子。在这篇综述中，我们全面概述了在正常和癌症条件下，GRP 在泌尿组织中的最新知识状态。GRP 和其受体 GRP-R 在正常肾脏和肾癌中表达。GRP 可刺激肾癌细胞的生长。GRP 和 GRP-R 在前列腺癌中表达，GRP 可刺激前列腺癌细胞系的生长。重要的是，GRP 是一种关键的神经内分泌肽，可能参与晚期前列腺癌的进展和前列腺癌的神经内分泌分化。最近的动物研究表明，GRP 和 GRP-R 是男性性功能的一个组成部分，在脊髓控制勃起和射精中起着至关重要的作用。
