Soylu Özler Gül, Akbay Ercan, Akkoca Ayşe Neslin, Karapınar Oya Soylu, Şimşek Gökçe Özel
Department of Otorhinolaryngology, Mustafa Kemal University, Hatay, Turkey,
Eur Arch Otorhinolaryngol. 2015 Feb;272(2):363-6. doi: 10.1007/s00405-014-3118-z. Epub 2014 Jun 4.
The aim of this study was to investigate the effect of menopause on nasal mucociliary clearance time by comparing the results of premenopausal and postmenopausal women. A total of 60 women met the criteria and were divided into two groups: premenopausal women (n = 30) and postmenopausal women (n = 30). Nasal mucociliary clearance time of these women was measured and compared. Moreover, the correlation between nasal mucociliary clearance time and menopause duration in postmenopausal women was evaluated. Statistical analysis was performed using the SPSS (Statistical Package for the Social Sciences) 13.0 Evaluation for Windows. Normal distribution of continuous variables was tested with Kolmogorov-Smirnov test. Chi square test was used for comparisons between categorical variables. Kruskal-Wallis test and Mann-Whitney U tests were used for continuous variables when comparing the groups. The statistically significant level was accepted as p value <0.05. The mean nasal mucociliary clearance time in premenopausal and postmenopausal women was 11.43 ± 2.81 (7-16) and 16.76 ± 2.73 (12-22), respectively. The mean nasal mucociliary clearance time in postmenopausal women was significantly longer than in premenopausal women (p < 0.0001). Also, there was positive correlation between menopause duration and nasal mucociliary clearance time in postmenopausal women (r = 0.833, p < 0.0001). The clinicians must keep in mind that nasal mucociliary clearance time in postmenopausal women is prolonged and must follow up women in postmenopausal period more closely for respiratory tract diseases, sinonasal and middle ear infections.
本研究的目的是通过比较绝经前和绝经后女性的结果，探讨绝经对鼻黏液纤毛清除时间的影响。共有60名女性符合标准，分为两组：绝经前女性（n = 30）和绝经后女性（n = 30）。测量并比较了这些女性的鼻黏液纤毛清除时间。此外，还评估了绝经后女性鼻黏液纤毛清除时间与绝经持续时间之间的相关性。使用SPSS（社会科学统计软件包）13.0 for Windows进行统计分析。连续变量的正态分布用Kolmogorov-Smirnov检验。卡方检验用于分类变量之间的比较。比较组间连续变量时，使用Kruskal-Wallis检验和Mann-Whitney U检验。统计学显著性水平被认为是p值<0.05。绝经前和绝经后女性的平均鼻黏液纤毛清除时间分别为11.43±2.81（7 - 16）和16.76±2.73（12 - 22）。绝经后女性的平均鼻黏液纤毛清除时间显著长于绝经前女性（p < 0.0001）。此外，绝经后女性的绝经持续时间与鼻黏液纤毛清除时间之间存在正相关（r = 0.833，p < 0.0001）。临床医生必须牢记，绝经后女性的鼻黏液纤毛清除时间会延长，对于呼吸道疾病、鼻窦和中耳感染，必须更密切地随访绝经后女性。
