Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Republic of Korea.
Biomed Res Int. 2014;2014:356080. doi: 10.1155/2014/356080. Epub 2014 May 8.
We investigated the association between the reduction in the estimated glomerular filtration rate (eGFR) and the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in Korean males.
We enrolled 723 healthy Korean males. Serum creatinine concentration, serum electrophoresis, serum immunofixation, and the serum free light chain assay were performed. We calculated delta eGFR per year (ΔeGFR/yr). The prevalence of MGUS was compared based on the ΔeGFR/yr and age group.
Thirteen (1.8%) of 723 participants exhibited the monoclonal band on serum immunofixation. Prevalence of MGUS by age group was 0.00% (0/172 for 40 years), 1.63% (6/367 for 60 years), and 3.80% (7/184 for >60 years). The median decrease in ΔeGFR/yr was 5.3%. The prevalence of MGUS in participants in their 50s with >5.3% decline in ΔeGFR/yr was significantly higher than those with <5.3% decrease in ΔeGFR/yr (3.16% versus 0.00%; P = 0.049). The prevalence of MGUS in participants in their 50s with >5.3% decrease in ΔeGFR/yr was similar to that of healthy males in their 60s.
Using the rate of reduction in ΔeGFR/yr in healthy Korean males who had their serum creatinine level checked regularly may increase the MGUS detection rate in clinical practice.
我们研究了估算肾小球滤过率（eGFR）降低与韩国男性意义未明单克隆丙种球蛋白病（MGUS）患病率之间的关系。
我们纳入了 723 名健康的韩国男性。检测了血清肌酐浓度、血清电泳、血清免疫固定和血清游离轻链分析。计算了每年的 eGFR 下降量（ΔeGFR/yr）。根据 ΔeGFR/yr 和年龄组比较了 MGUS 的患病率。
13 名（1.8%）参与者的血清免疫固定出现了单克隆带。按年龄组划分，MGUS 的患病率分别为 0.00%（0/172 岁）、1.63%（6/367 岁）和 3.80%（7/184 岁）。ΔeGFR/yr 的中位数下降量为 5.3%。在 50 多岁的参与者中，ΔeGFR/yr 下降幅度>5.3%者的 MGUS 患病率显著高于ΔeGFR/yr 下降幅度<5.3%者（3.16%与 0.00%；P=0.049）。在 50 多岁的参与者中，ΔeGFR/yr 下降幅度>5.3%者的 MGUS 患病率与 60 多岁的健康男性相似。
使用定期检测血清肌酐水平的韩国健康男性的ΔeGFR/yr 下降率可能会提高临床实践中的 MGUS 检出率。
