乳腺癌患者循环肿瘤细胞中干细胞和上皮-间充质转化标志物的表达。
Expression of stem cell and epithelial-mesenchymal transition markers in circulating tumor cells of breast cancer patients.
机构信息
Department of Obstetrics and Gynecology, University of Duesseldorf, Moorenstraße 5, 40225 Duesseldorf, Germany.
出版信息
Biomed Res Int. 2014;2014:415721. doi: 10.1155/2014/415721. Epub 2014 May 8.
Abstract
Evaluation and characterization of circulating tumor cells (CTCs) have become a major focus of translational cancer research. Presence of CTCs predicts worse clinical outcome in early and metastatic breast cancer. Whether all cells from the primary tumor have potential to disseminate and form subsequent metastasis remains unclear. As part of the metastatic cascade, tumor cells lose their cell-to-cell adhesion and undergo epithelial-mesenchymal transition (EMT) in order to enter blood circulation. During EMT epithelial antigens are downregulated; thus, such tumor cells might elude classical epithelial marker-based detection. Several researchers postulated that some CTCs express stem cell-like phenotype; this might lead to chemoresistance and enhanced metastatic potential of such cells. In the present review, we discuss current data on EMT and stem cell markers in CTCs of breast cancer and their clinical significance.
摘要
循环肿瘤细胞（CTCs）的评估和表征已成为转化癌症研究的主要焦点。CTCs 的存在可预测早期和转移性乳腺癌的临床预后更差。原发肿瘤的所有细胞是否都有可能扩散并形成随后的转移尚不清楚。作为转移级联的一部分，肿瘤细胞失去细胞间黏附，并经历上皮-间充质转化（EMT）以进入血液循环。在 EMT 过程中，上皮抗原下调；因此，这些肿瘤细胞可能逃避基于经典上皮标志物的检测。一些研究人员推测，一些 CTC 表达干细胞样表型；这可能导致这些细胞的化疗耐药性和增强的转移潜能。在本综述中，我们讨论了乳腺癌 CTC 中 EMT 和干细胞标志物的最新数据及其临床意义。
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