免疫组织化学检测发现，BAG3与HIF-1α共表达与肝移植后肝细胞癌的预后相关。
BAG3 and HIF-1 α coexpression detected by immunohistochemistry correlated with prognosis in hepatocellular carcinoma after liver transplantation.
作者信息
Xiao Heng, Tong Rongliang, Cheng Shaobing, Lv Zhen, Ding Chaofeng, Du Chengli, Xie Haiyang, Zhou Lin, Wu Jian, Zheng Shusen
机构信息
Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China ; Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou 310003, China.
Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
出版信息
Biomed Res Int. 2014;2014:516518. doi: 10.1155/2014/516518. Epub 2014 May 8.
OBJECTIVE
The objective is to determine the effects of BAG3 and HIF-1 α expression on the prognosis of HCC patients after liver transplantation.
METHODS
Samples from 31 patients with HCC receiving liver transplantation were collected for this study. The immunohistochemistry was used to detect the expression of BAG3 and HIF-1 α of HCC samples.
RESULTS
According to the immunohistochemistry results, BAG3 and HIF-1 α staining were significantly associated with tumor TNM stage (P = 0.004, P = 0.012). A significant association between high BAG3/HIF-1 α levels and a shorter overall survival was detected, so as the combined BAG3 and HIF-1 α analysis.
CONCLUSION
The results suggested that the expression level of BAG3 and HIF-1 α is efficient prognostic parameters in patients with HCC after liver transplantation.
目的
本研究旨在确定BAG3和HIF-1α表达对肝癌患者肝移植术后预后的影响。
方法
本研究收集了31例接受肝移植的肝癌患者的样本。采用免疫组织化学法检测肝癌样本中BAG3和HIF-1α的表达。
结果
根据免疫组织化学结果，BAG3和HIF-1α染色与肿瘤TNM分期显著相关（P = 0.004，P = 0.012）。检测到高BAG3/HIF-1α水平与较短的总生存期之间存在显著关联，BAG3和HIF-1α联合分析也是如此。
结论
结果表明，BAG3和HIF-1α的表达水平是肝癌患者肝移植术后有效的预后参数。
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