Fidelta d.o.o., Prilaz baruna Filipovića 29, HR-10000 Zagreb, Croatia.
Future Med Chem. 2014 Apr;6(6):657-74. doi: 10.4155/fmc.14.14.
Neutrophil-dominated inflammatory diseases, like chronic obstructive pulmonary disease, cystic fibrosis, bronchiectasis, bronchiolitis obliteras syndrome and non-eosinophilic asthma, present a significant medical problem lacking adequate therapy. Macrolide antibiotics have been reported to be effective in the treatment of the aforementioned diseases, for reasons unrelated to their antibacterial action. This has resulted in research activities aimed at gaining a better understanding of the immunomodulatory actions of macrolides and the synthesis of various novel anti-inflammatory macrolides without antimicrobial activity. Despite the difficult chemistry and lack of an extensive knowledge for their mechanism of action, several interesting molecules from this class, including potential clinical candidates, are on the horizon.
中性粒细胞为主的炎症性疾病，如慢性阻塞性肺疾病、囊性纤维化、支气管扩张症、闭塞性细支气管炎综合征和非嗜酸性哮喘，是一个严重的医学问题，缺乏有效的治疗方法。大环内酯类抗生素已被报道在上述疾病的治疗中有效，原因与它们的抗菌作用无关。这导致了旨在更好地了解大环内酯类的免疫调节作用和合成各种新型无抗菌活性的抗炎大环内酯类的研究活动。尽管化学性质复杂，作用机制知之甚少，但该类药物中有几个有趣的分子，包括有潜力的临床候选药物，正在崭露头角。
