Dell'Omo G, Fiore M, Alleva E
Section of Behavioural Pathophysiology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161 Rome, Italy.
Behav Processes. 1994 Aug;32(2):105-15. doi: 10.1016/0376-6357(94)90069-8.
Sexually mature male mice of three different strains (CD-1 outbred, CBA, and C57BI/6J inbred) were exposed in an arena to a small black cylinder (35 mm film container), filled with faeces of either a mouse predator (red fox, Vulpes vulpes) or a non-predator (rabbit, Oryctolagus cuniculus) during a 3 min test. Control animals were given an empty container. Locomotor activity and behavioural responses in the arena were scored. Hot-plate response (50 ± 0.5°C) was measured 15 min before and immediately after exposure to the odour. Responses to predators were found to be strain-specific. In CD-1 and C57 mice, latency of approach to the small cylinder increased while contacts with it decreased upon fox odour exposure. In CBA mice, fox odour caused an increase of defensive burying and sniffing, and a decrease of rearing. Odour exposure did not affect grooming, digging, or wall rearing in any of the strains. Hot-plate analgesia was also unaffected. The observed strain differences in the defensive response, interpreted as evolutionary adaptive anti-predatory strategies, seem to confirm the suggested origin of the two inbred strains used.
在一项3分钟的测试中，将三种不同品系（远交系CD-1、近交系CBA和C57BI/6J）性成熟的雄性小鼠置于一个场地中，使其接触一个黑色小圆柱体（35毫米胶卷盒），该圆柱体中装有鼠类捕食者（赤狐，赤狐属）或非捕食者（兔子，穴兔属）的粪便。对照组动物则给予一个空容器。对场地中的运动活动和行为反应进行评分。在接触气味前15分钟和接触后立即测量热板反应（50±0.5°C）。发现对捕食者的反应具有品系特异性。在CD-1和C组小鼠中，接触狐狸气味后，接近小圆柱体的潜伏期增加，而与之接触的次数减少。在CBA小鼠中，狐狸气味导致防御性掩埋和嗅闻增加，而竖毛减少。气味暴露对任何品系的梳理、挖掘或靠墙竖毛均无影响。热板镇痛也未受影响。观察到的防御反应中的品系差异被解释为进化适应性反捕食策略，这似乎证实了所用两种近交系的推测起源。
