China Department of Radiology, Shanghai Ruijin Hospital, No, 197 Ruijin Er Rd, Shanghai, 200011.
Front Biosci (Landmark Ed). 2014 Jun 1;19(8):1377-85. doi: 10.2741/4288.
In this study, we aimed to explore the potential of dual-energy computed tomography (DECT) in evaluating liver fat; we also compared the diagnostic performance of DECT, T1-weighted dual-echo magnetic resonance (MR) imaging, and 1H-MR spectroscopy (1H-MRS) in assessing hepatic steatosis in a fatty liver rat model. Fat (water) concentration measurements by DECT spectral imaging, MR findings, and 1H-MRS measurements of hepatic fat showed similar correlations with the histopathologic results. Furthermore, a good correlation was observed between the fat (water) concentration and 1H-MRS measurements (r = 0.800 and P less than 0.001). The discriminant accuracies of the fat (water) concentration, MR findings, and 1H-MRS measurements were 66.7, 64, and 56 percent, respectively. Therefore, we conclude that the findings of DECT spectral CT imaging are strongly correlated with histopathologic findings in cases of steatosis; in addition, DECT can allow rapid, accurate evaluations of hepatic steatosis that are as effective as those obtained using T1-weighted dual-echo MR imaging and 1H-MRS.
在这项研究中，我们旨在探索双能 CT（DECT）在评估肝脂肪方面的潜力；我们还比较了 DECT、T1 加权双回波磁共振成像（MR）和 1H-MR 光谱（1H-MRS）在评估脂肪肝大鼠模型中肝脂肪变性的诊断性能。DECT 能谱成像、MR 结果和肝脂肪的 1H-MRS 测量的脂肪（水）浓度测量与组织病理学结果具有相似的相关性。此外，脂肪（水）浓度与 1H-MRS 测量之间存在良好的相关性（r = 0.800，P 小于 0.001）。脂肪（水）浓度、MR 发现和 1H-MRS 测量的判别准确率分别为 66.7%、64%和 56%。因此，我们得出结论，DECT 能谱 CT 成像的发现与脂肪变性的组织病理学发现具有很强的相关性；此外，DECT 可以快速、准确地评估肝脂肪变性，其效果与 T1 加权双回波 MR 成像和 1H-MRS 相当。
