School of Nursing,Central South University,172 Tongzipo Road,Changsha 410013,Hunan,China.
Front Biosci (Landmark Ed). 2014 Jun 1;19(8):1411-7. doi: 10.2741/4291.
The extracellular signal-regulated kinase (ERK) signaling pathway participates in various cell responses, such as proliferation, migration, differentiation and death. In neuronal apoptosis, the ERK pathway has been shown to have a dual role. Although the majority of studies have demonstrated the ERK pathway to have an anti-apoptotic role in neurons, pro-apoptosis induced by ERK signaling, has also been observed. The different effects of the ERK pathway may be due to the different kinds of neurons used in these studies, stimulus, interplay with other MAPK pathways and maybe other as yet unclear factors. In this review, we will summarize the role of the ERK signaling pathway in the apoptosis of neurons.
细胞外信号调节激酶（ERK）信号通路参与多种细胞反应，如增殖、迁移、分化和死亡。在神经元凋亡中，ERK 通路被证明具有双重作用。尽管大多数研究表明 ERK 通路在神经元中具有抗凋亡作用，但也观察到 ERK 信号诱导的促凋亡作用。ERK 通路的不同作用可能是由于这些研究中使用的神经元种类不同、刺激不同、与其他 MAPK 通路的相互作用以及其他尚未清楚的因素。在这篇综述中，我们将总结 ERK 信号通路在神经元凋亡中的作用。
