丝裂原活化蛋白激酶/细胞外信号调节激酶（MAPK/ERK）在细胞增殖、分化、迁移、衰老和凋亡中的信号通路。
Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis.
作者信息
Sun Yu, Liu Wen-Zhou, Liu Tao, Feng Xu, Yang Nuo, Zhou Hua-Fu
机构信息
a Department of Cardio-Thoracic Surgery , The First Affiliated Hospital of GuangXi Medical University , Nanning , P.R. China.
出版信息
J Recept Signal Transduct Res. 2015;35(6):600-4. doi: 10.3109/10799893.2015.1030412. Epub 2015 Jun 22.
The generic mitogen-activated protein kinases (MAPK) signaling pathway is shared by four distinct cascades, including the extracellular signal-related kinases (ERK1/2), Jun amino-terminal kinases (JNK1/2/3), p38-MAPK and ERK5. Mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) pathway is reported to be associated with the cell proliferation, differentiation, migration, senescence and apoptosis. The literatures were searched extensively and this review was performed to review the role of MAPK/ERK signaling pathway in cell proliferation, differentiation, migration, senescence and apoptosis.
通用的丝裂原活化蛋白激酶（MAPK）信号通路由四个不同的级联反应共享，包括细胞外信号调节激酶（ERK1/2）、Jun氨基末端激酶（JNK1/2/3）、p38-MAPK和ERK5。据报道，丝裂原活化蛋白激酶/细胞外信号调节激酶（MAPK/ERK）通路与细胞增殖、分化、迁移、衰老和凋亡有关。我们广泛检索了文献，并进行了本综述以探讨MAPK/ERK信号通路在细胞增殖、分化、迁移、衰老和凋亡中的作用。
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