Hamada S
Kanagawa Shigaku. 1989 Jun;24(1):24-37.
It is well documented that uptake of various trace elements take place during tooth development. The purpose of this experiment was to analyze the uptake amount of these various trace elements, in particular Cd, Zn, Pb and Cu throughout the tooth germ formation all the way up to the eruption stage. Bovine permanent tooth germs were used in this experiment. Instead of the conventional morphologic stages, further subdivision into eight groups were employed. The resultant findings were as follows: 1) Uptake of Cd and Zn were verified during the root development to early tooth eruption stage in enamel. Meanwhile, for dentin, the uptake was corroborated from the root development to the late tooth eruption stage. 2) Uptake of Cu was verified during the late tooth eruption stage in enamel. However, no uptake occurred in dentin in any of the various stages. 3) Uptake of Pb occurred during the late tooth eruption stage in enamel. Meanwhile, in dentin, constant equivalent amount of uptake was seen throughout all of the stages. 4) Quantitative analysis of the Cd, Zn and Pb uptake in both enamel and dentin clearly indicated that enamel showed much higher values. The uptake of Cu was found to be significantly high in the groups of the coronal one-third and the eruption four-fifth groups for enamel. Meanwhile, the crown completion group to the half erupted group showed significantly high values for dentin. Based on the above findings, one can deduce clear correlation between enamel organ development and the uptake of the said various trace elements.
有充分的文献记载,在牙齿发育过程中会摄取各种微量元素。本实验的目的是分析这些各种微量元素,特别是镉、锌、铅和铜在整个牙胚形成直至萌出阶段的摄取量。本实验使用牛恒牙胚。与传统的形态学阶段不同,进一步细分为八组。结果如下:1)在牙根发育至釉质早期萌出阶段证实有镉和锌的摄取。同时,对于牙本质,从牙根发育至牙齿晚期萌出阶段均证实有摄取。2)在釉质牙齿晚期萌出阶段证实有铜的摄取。然而,在牙本质的任何阶段均未发生摄取。3)在釉质牙齿晚期萌出阶段发生铅的摄取。同时,在牙本质中,在所有阶段均可见恒定等量的摄取。4)对釉质和牙本质中镉、锌和铅摄取的定量分析清楚地表明,釉质显示出高得多的值。发现铜的摄取在釉质的冠部三分之一组和萌出五分之四组中显著较高。同时,牙本质的冠部完成组至半萌出组显示出显著较高的值。基于上述发现,可以推断出牙釉质器官发育与上述各种微量元素摄取之间存在明显的相关性。