大鼠新奇诱导活动的个体差异以及新奇和苯丙胺的奖赏效应。
Individual differences in novelty-induced activity and the rewarding effects of novelty and amphetamine in rats.
作者信息
Robinet P M, Rowlett J K, Bardo M T
机构信息
Department of Psychology, Colby College, Waterville, MN 04901, USA.
Harvard Medical School, New England Regional Primate Research Center, One Pine Hill Drive, Southborough, MA 01772, USA.
出版信息
Behav Processes. 1998 Jul;44(1):1-9. doi: 10.1016/s0376-6357(98)00022-9.
Previous work has shown that individual differences in locomotor behavior in an inescapable novel environment predict the locomotor-stimulant effect of amphetamine. Experiment 1 of the present study assessed if novelty-seeking behavior in a free choice situation also predicts the locomotor-stimulant effect of amphetamine. Rats were first assessed for their locomotor response to an inescapable novel environment and then were allowed to choose between this environment (familiar) and a novel environment. Activity in the inescapable novel environment was found to predict subsequent locomotor response to amphetamine, but approach to novelty in the free choice situation did not. In experiment 2, rats were assessed for their approach to novelty in the free choice situation and then assessed for amphetamine-induced conditioned place preference. It was found that rats who spent more time in a novel environment also showed a higher magnitude of amphetamine-induced conditioned place preference. These findings are consistent with the hypothesis that the rewarding properties of novelty and amphetamine may be mediated by a similar brain mechanism.
先前的研究表明，在无法逃避的新环境中运动行为的个体差异可预测苯丙胺的运动刺激作用。本研究的实验1评估了在自由选择情境下的新奇寻求行为是否也能预测苯丙胺的运动刺激作用。首先评估大鼠对无法逃避的新环境的运动反应，然后让它们在这个环境（熟悉环境）和一个新环境之间进行选择。结果发现，在无法逃避的新环境中的活动可预测随后对苯丙胺的运动反应，但在自由选择情境下对新奇事物的趋近行为则不能。在实验2中，评估大鼠在自由选择情境下对新奇事物的趋近行为，然后评估苯丙胺诱导的条件性位置偏爱。结果发现，在新环境中停留时间更长的大鼠，其苯丙胺诱导的条件性位置偏爱程度也更高。这些发现与以下假设一致，即新奇事物和苯丙胺的奖赏特性可能由相似的脑机制介导。
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