HIV 阴性和 HIV 感染的男男性行为者口腔 HPV 感染的六个月发病率和持续情况。
Six-month incidence and persistence of oral HPV infection in HIV-negative and HIV-infected men who have sex with men.
作者信息
Mooij Sofie H, Boot Hein J, Speksnijder Arjen G C L, Meijer Chris J L M, King Audrey J, Verhagen Dominique W M, de Vries Henry J C, Quint Wim G V, Molijn Anco, de Koning Maurits N C, van der Sande Marianne A B, van der Loeff Maarten F Schim
机构信息
Cluster of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, the Netherlands; Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
出版信息
PLoS One. 2014 Jun 4;9(6):e98955. doi: 10.1371/journal.pone.0098955. eCollection 2014.
OBJECTIVES
Our aim was to assess incidence and persistence of oral HPV infection in HIV-negative and HIV-infected men who have sex with men (MSM).
METHODS
MSM aged ≥18 years were included in Amsterdam (the Netherlands) in 2010-2011, and followed up 6 months later. Participants completed risk factor questionnaires. HPV DNA was analyzed in oral-rinse and gargle specimens using the SPF10-PCR DEIA/LiPA25 system (version 1). A subset of oral samples was subjected to SPF10 sequencing to identify additional HPV types. Multivariable logistic regression analyses using generalized estimating equations (GEE) were performed to assess determinants for oral high-risk HPV incidence and persistence.
RESULTS
689/795 participant MSM provided both baseline and 6-month data. Baseline prevalence of high-risk HPV was 9.4% in HIV-negative and 23.9% in HIV-infected MSM (P<0.001). 56/689 MSM acquired ≥1 high-risk HPV infection (6-month incidence 8.1%; 95%CI 6.2-10.4%); incidence was 4.1% in HIV-negative and 14.1% in HIV-infected MSM (P<0.001). HIV infection and recent use of cannabis were both independently associated with high-risk HPV incidence. Persistent high-risk HPV was observed in 48/130 (36.9%) infections.
CONCLUSION
Incidence of oral high-risk HPV infection in MSM is substantial, and is associated with HIV infection. Over a third of HPV infections persisted over a 6-month period.
目的
我们的目的是评估HIV阴性和HIV感染的男男性行为者（MSM）中口腔HPV感染的发生率和持续性。
方法
2010年至2011年在荷兰阿姆斯特丹纳入了年龄≥18岁的MSM，并在6个月后进行随访。参与者完成了风险因素问卷。使用SPF10-PCR DEIA/LiPA25系统（版本1）对口腔冲洗和漱口标本中的HPV DNA进行分析。对一部分口腔样本进行SPF10测序以鉴定其他HPV类型。使用广义估计方程（GEE）进行多变量逻辑回归分析，以评估口腔高危HPV感染发生率和持续性的决定因素。
结果
689/795名参与的MSM提供了基线和6个月的数据。HIV阴性MSM中高危HPV的基线患病率为9.4%，HIV感染的MSM中为23.9%（P<0.001）。56/689名MSM获得了≥1种高危HPV感染（6个月发生率8.1%；95%CI 6.2-10.4%）；HIV阴性MSM中的发生率为4.1%，HIV感染的MSM中为14.1%（P<0.001）。HIV感染和近期使用大麻均与高危HPV感染发生率独立相关。在130例感染中有48例（36.9%）观察到持续性高危HPV。
结论
MSM中口腔高危HPV感染的发生率很高，并且与HIV感染有关。超过三分之一的HPV感染在6个月内持续存在。
Zotero 插件