Zhang Chaoting, Liu Fangfang, Pan Yaqi, Deng Qiuju, Li Xiang, He Zhonghu, Liu Mengfei, Ning Tao, Guo Chuanhai, Liang Yongmei, Xu Ruiping, Zhang Lixin, Cai Hong, Ke Yang
Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Laboratory of Genetics, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Anyang Cancer Hospital, Anyang 455000, China.
Oncotarget. 2017 Mar 17;8(35):59831-59844. doi: 10.18632/oncotarget.16306. eCollection 2017 Aug 29.
The natural history of oral human papillomavirus (HPV) infection which is linked with the increased incidence of oropharyngeal squamous cell cancer (OPSCC) has been incompletely studied. Oral swab specimens and questionnaire data were obtained bi-annually for up to 6 visits from 4314 healthy adults aged 25-69 in rural Anyang, China. HPV infection status was evaluated with PCR-based sequencing. Participants with at least two consecutive valid HPV results within the study period were included in the incidence and clearance analysis. Among 3289 participants included in this analysis (median follow-up time 18.3 months), incidence rates of mucosal HPV, oncogenic mucosal HPV and cutaneous HPV were 0.53 (95% CI: 0.39-0.73), 0.30 (95% CI: 0.20-0.46), and 4.17 (95% CI: 3.70-4.70) per 1,000 person-months respectively. Most newly acquired infections were cleared within one year. Recent practice of oral sex increased the risk of incident infection with mucosal HPV (Adjusted HR, 5.03; 95% CI, 1.16-21.73) and oncogenic mucosal HPV (Adjusted HR, 10.13; 95% CI, 2.14-48.06). Newly acquired oral mucosal HPV infections are rare and most are cleared within one year in rural Chinese. This study expands understanding of the natural history of oral HPV in countries with a lower incidence of HPV-OPSCC.
与口咽鳞状细胞癌（OPSCC）发病率增加相关的口腔人乳头瘤病毒（HPV）感染的自然史尚未得到充分研究。在中国安阳农村地区，每半年从4314名年龄在25 - 69岁的健康成年人中获取口腔拭子标本和问卷调查数据，共进行6次。采用基于聚合酶链反应（PCR）的测序技术评估HPV感染状况。在研究期间至少有两个连续有效HPV检测结果的参与者被纳入发病率和清除率分析。在纳入该分析的3289名参与者中（中位随访时间18.3个月），黏膜HPV、致癌性黏膜HPV和皮肤HPV的发病率分别为每1000人月0.53（95%置信区间：0.39 - 0.73）、0.30（95%置信区间：0.20 - 0.46）和4.17（95%置信区间：3.70 - 4.70）。大多数新获得的感染在一年内清除。近期的口交行为增加了黏膜HPV（校正风险比，5.03；95%置信区间，1.16 - 21.73）和致癌性黏膜HPV（校正风险比，10.13；95%置信区间，2.14 - 48.06）感染的风险。在中国农村，新获得的口腔黏膜HPV感染很少见，且大多数在一年内清除。本研究扩展了对HPV - OPSCC发病率较低国家口腔HPV自然史的认识。
