Heller K E
Zoological Laboratory, University of Copenhagen, Universitetsparken 15, 2100 Copenhagen Denmark.
Behav Processes. 1979 Oct;4(3):231-8. doi: 10.1016/0376-6357(79)90004-4.
One experiment was conducted to separate the roles of corticosterone and ACTH in the mediation of the facilitatory effects of experiencing shock on subsequent fighting behaviour in male mice. It was found that (1) treatment with electric foot-shock and single injections of ACTH (one dose level) lead to comparable increases in subsequent fighting in intact males; (2) preventing changes in testosterone secretion by combined castration and testosterone replacement does not occlude or modify the facilitatory effects of shock or ACTH on subsequent fighting; and (3) preventing changes in both testosterone and corticosterone secretion by combined castration-adrenalectomy and testosterone-corticosterone replacement prevents shock and ACTH induced increases in fighting. These findings suggest that corticosterone plays a more important role than ACTH in the mediation of the facilitatory effects of shock on subsequent fighting behaviour in male mice.
进行了一项实验，以区分皮质酮和促肾上腺皮质激素（ACTH）在介导遭受电击对雄性小鼠后续战斗行为的促进作用中的角色。结果发现：（1）用足部电击处理以及单次注射ACTH（一个剂量水平）会使完整雄性小鼠的后续战斗行为有相当程度的增加；（2）通过联合阉割和睾酮替代来防止睾酮分泌变化，并不会消除或改变电击或ACTH对后续战斗的促进作用；（3）通过联合阉割-肾上腺切除术以及睾酮-皮质酮替代来防止睾酮和皮质酮分泌变化，可防止电击和ACTH诱导的战斗行为增加。这些发现表明，在介导电击对雄性小鼠后续战斗行为的促进作用方面，皮质酮比ACTH发挥着更重要的作用。
