Brain P F, Evans A E
Pharmacol Biochem Behav. 1977 Nov;7(5):425-33. doi: 10.1016/0091-3057(77)90210-6.
A number of corticotrophin preparations when given acutely enhanced fighting behavior, an event which may be consequent upon elevation of circulating corticosterone. A series of short ACTH analogues (ACTH 11-24, ACTH 4-10) had slight influences on circulating plasma corticosterone values and on fighting behavior. However, 20 microgram ACTH 1-10 given 12 hr before testing did increase fighting C.F. controls. As this compound only caused a slight stimulation of plasma corticosterone titers, the possibility exists of an extra-adrenal influence. One cannot, it appears, eliminate glucocorticoid influences using these preparations in the mouse. Acutely, ACTH 1-24 had virtually no influences on Animex-assessed motor activity but did enhance fighting in castrated mice maintained with either androgen or estrogen. It is tentatively concluded that the ACTH influences on aggression in the mouse are partially mediated via glucocorticoid influences on the CNS combined with an extra adrenal influence of part of the ACTH molecule. A possible reason for the differing acute and chronic influences of ACTH on fighting in mice is presented.
一些促肾上腺皮质激素制剂在急性给药时会增强攻击行为，这一事件可能是循环皮质酮升高的结果。一系列短链促肾上腺皮质激素类似物（促肾上腺皮质激素11 - 24、促肾上腺皮质激素4 - 10）对循环血浆皮质酮值和攻击行为有轻微影响。然而，在测试前12小时给予20微克促肾上腺皮质激素1 - 10确实增加了攻击行为（与对照组相比）。由于这种化合物仅引起血浆皮质酮滴度的轻微刺激，因此存在肾上腺外影响的可能性。看来，在小鼠中使用这些制剂无法消除糖皮质激素的影响。急性情况下，促肾上腺皮质激素1 - 24对通过Animex评估的运动活动几乎没有影响，但确实增强了用雄激素或雌激素维持的去势小鼠的攻击行为。初步得出结论，促肾上腺皮质激素对小鼠攻击行为的影响部分是通过糖皮质激素对中枢神经系统的影响以及促肾上腺皮质激素分子部分的肾上腺外影响介导的。本文还提出了促肾上腺皮质激素对小鼠攻击行为产生不同急性和慢性影响的一个可能原因。
