乙胺丁醇过度治疗导致的视交叉和周围神经病变。

Optochiasmatic and peripheral neuropathy due to ethambutol overtreatment.

作者信息

Geyer Howard L, Herskovitz Steven, Slamovits Thomas L, Schaumburg Herbert H

机构信息

Saul R. Korey Department of Neurology (HLG, SH, TLS, HHS), Department of Ophthalmology and Visual Sciences (TLS), and Leo M. Davidoff Department of Neurological Surgery (TLS), Albert Einstein College of Medicine, Bronx, New York.

出版信息

J Neuroophthalmol. 2014 Sep;34(3):257-8. doi: 10.1097/WNO.0000000000000141.

DOI:10.1097/WNO.0000000000000141

PMID:24897009

Abstract

Ethambutol is known to cause optic neuropathy and, more rarely, axonal polyneuropathy. We characterize the clinical, neurophysiological, and neuroimaging findings in a 72-year-old man who developed visual loss and paresthesias after 11 weeks of exposure to a supratherapeutic dose of ethambutol. This case demonstrates the selective vulnerability of the anterior visual pathways and peripheral nerves to ethambutol toxicity.

摘要

已知乙胺丁醇会导致视神经病变，更罕见的是会引发轴索性多发性神经病。我们描述了一名72岁男性的临床、神经生理学和神经影像学检查结果，该患者在接受超治疗剂量乙胺丁醇11周后出现视力丧失和感觉异常。此病例证明了乙胺丁醇毒性对视觉前通路和周围神经具有选择性易损性。