Melamud Alex, Kosmorsky Gregory S, Lee Michael S
Cole Eye Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Mayo Clin Proc. 2003 Nov;78(11):1409-11. doi: 10.4065/78.11.1409.
Ethambutol is an antimicrobial agent used frequently to treat tuberculosis. The most commonly recognized toxic effect of ethambutol is optic neuropathy, which generally is considered uncommon and reversible in medical literature. We describe a 43-year-old man who developed signs and symptoms of bilateral optic neuropathy during treatment with ethambutol. This case and a review of the literature show the severe and unpredictable nature of ethambutol toxicity and its potential for irreversible vision loss despite careful ophthalmologic monitoring.
乙胺丁醇是一种常用于治疗结核病的抗菌药物。乙胺丁醇最常见的毒性作用是视神经病变，在医学文献中，这通常被认为不常见且是可逆的。我们描述了一名43岁男性，他在接受乙胺丁醇治疗期间出现了双侧视神经病变的体征和症状。该病例及文献综述表明，尽管进行了仔细的眼科监测，但乙胺丁醇毒性具有严重且不可预测的性质，并有导致不可逆视力丧失的可能性。
