Tuchinda Papapit, Ritchie Simon, Gaspari Anthony A
Department of Dermatology, University of Maryland School of Medicine, 419 W Redwood St, Ste 240, Baltimore, MD 21201, USA.
Cutis. 2014 May;93(5):264-8.
Bullous pemphigoid (BP) is a blistering autoimmune disease that primarily affects elderly patients who commonly present with comorbidities. Side effects from long-term treatment with conventional cytotoxic and immunosuppressive agents may increase morbidity and mortality in this patient population. We present a case of BP in a 78-year-old woman with an active pulmonary Mycobacterium avium-intracellulare complex (MAC) infection that precluded the use of systemic corticosteroids or other immunosuppressants. Our patient was successfully treated with intravenous immunoglobulin (IVIG) monotherapy, which may provide an alternative treatment option for BP patients who are unable to tolerate cytotoxic or immunosuppressive therapies.
大疱性类天疱疮（BP）是一种水疱性自身免疫性疾病，主要影响常伴有合并症的老年患者。传统细胞毒性和免疫抑制剂的长期治疗副作用可能会增加该患者群体的发病率和死亡率。我们报告一例78岁女性大疱性类天疱疮患者，其患有活动性鸟分枝杆菌胞内复合群（MAC）肺部感染，无法使用全身性皮质类固醇或其他免疫抑制剂。我们的患者通过静脉注射免疫球蛋白（IVIG）单一疗法成功治愈，这可能为无法耐受细胞毒性或免疫抑制疗法的大疱性类天疱疮患者提供了一种替代治疗选择。
