State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai, 200050, P. R. China.
Adv Healthc Mater. 2015 Jan 7;4(1):158-65. doi: 10.1002/adhm.201400127. Epub 2014 Jun 4.
The successful cancer eradication in a noninvasive manner is the ultimate objective in the fight against cancer. As a "bloodless scalpel," high-intensity focused ultrasound (HIFU) is regarded as one of the most promising and representative noninvasive therapeutic modalities for cancer surgery. However, large-scale clinical applications of HIFU are still in their infancy because of critical efficiency and safety issues which remain to be solved. Fortunately, recently developed nanobiotechnology provides an alternative efficient approach to improve such important issues in HIFU, especially for cancer therapy. This Research News presents the very recent exciting progresses on the elaborate design and fabrication of organic, inorganic, and organic/inorganic hybrid nanoparticles for enhancing the HIFU ablation efficiency against tumor tissues. It is highly expected that this Research News can arouse more extensive research enthusiasm on the development of functional nanomaterials for highly efficient HIFU-based synergistic therapy, which will give a promising noninvasive therapeutic modality for the successful cancer therapy with minimal damage to surrounding normal tissues, due to the noninvasive and site-specific therapeutic features of HIFU.
以非侵入的方式成功消灭癌症是对抗癌症的最终目标。高强度聚焦超声（HIFU）作为一种“无血手术刀”，被认为是癌症手术最有前途和代表性的非侵入性治疗方式之一。然而，由于仍需要解决关键的效率和安全问题，HIFU 的大规模临床应用仍处于起步阶段。幸运的是，最近发展起来的纳米生物技术为改善 HIFU 中的这些重要问题提供了一种替代的有效方法，特别是在癌症治疗方面。这篇研究新闻介绍了在精心设计和制造有机、无机和有机/无机杂化纳米粒子以提高针对肿瘤组织的 HIFU 消融效率方面的最新令人兴奋的进展。人们高度期望这篇研究新闻能够激发更多关于开发高效基于 HIFU 的协同治疗的功能纳米材料的研究热情，由于 HIFU 的非侵入性和特定部位治疗的特点，这将为成功治疗癌症并将对周围正常组织的损伤降至最低提供一种有前途的非侵入性治疗方式。
