Zeng Zeng, Liu Ji-Bin, Peng Cheng-Zhong
Department of Ultrasound, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, USA.
Curr Med Chem. 2022 Mar 4;29(8):1369-1378. doi: 10.2174/0929867328666210708085110.
This review describes how phase-changeable nanoparticles enable highly-efficient high-intensity focused ultrasound ablation (HIFU). HIFU is effective in the clinical treatment of solid malignant tumors; however, it has intrinsic disadvantages for treating some deep lesions, such as damage to surrounding normal tissues. When phase-changeable nanoparticles are used in HIFU treatment, they could serve as good synergistic agents because they are transported in the blood and permeated and accumulated effectively in tissues. HIFU's thermal effects can trigger nanoparticles to undergo a special phase transition, thus enhancing HIFU ablation efficiency. Nanoparticles can also carry anticancer agents and release them in the targeted area to achieve chemo-synergistic therapy response. Although the formation of nanoparticles is complicated and HIFU applications are still in an early stage, the potential for their use in synergy with HIFU treatment shows promising results.
本综述描述了相变纳米颗粒如何实现高效高强度聚焦超声消融（HIFU）。HIFU在实体恶性肿瘤的临床治疗中是有效的；然而，在治疗一些深部病变时它存在固有缺点，比如对周围正常组织的损伤。当将相变纳米颗粒用于HIFU治疗时，它们可作为良好的协同剂，因为它们在血液中运输并能有效渗透和积聚在组织中。HIFU的热效应可触发纳米颗粒发生特殊的相变，从而提高HIFU消融效率。纳米颗粒还可携带抗癌剂并在靶向区域释放，以实现化学协同治疗反应。尽管纳米颗粒的形成过程复杂且HIFU应用仍处于早期阶段，但它们与HIFU治疗协同使用的潜力显示出了令人期待的结果。
