Hong Song H, Al-Ruthia Yazed, Tak Sunghee
Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Clin Transl Sci. 2014 Oct;7(5):376-83. doi: 10.1111/cts.12174. Epub 2014 Jun 5.
While time-release (TR) formulations reduce medication complexity, their increased costs may compromise medication affordability. This study examined how medication complexity and affordability affect the extent of access to TR formulations among adult patients with depression. Study subjects consisted of adults (≥ 24 years old) with reported diagnoses of depression from the 2010 Medical Expenditure Panel Survey (MEPS). Antidepressants that offer choices between TR vs. IR (immediate release) were selected. Factors related to medication complexity and affordability were identifi ed based on the Andersonfs model of health services utilization. A multivariate logistic regression was used to examine the study hypotheses while controlling for complex survey sampling in MEPS. A total of 625 working adults with depression had fi lled prescriptions with TR formulations about 60% of the time. Factors related to medication affordability and complexity were signifi cantly associated with the extent of access to TR antidepressant formulations. Identifi cation of those factors associated with the use of TR formulations would contribute to improving access as well as adherence to antidepressant drug therapy.
虽然缓释（TR）制剂降低了用药复杂性，但其成本增加可能会影响药物的可负担性。本研究调查了用药复杂性和可负担性如何影响成年抑郁症患者使用TR制剂的程度。研究对象包括2010年医疗支出面板调查（MEPS）中报告诊断为抑郁症的成年人（≥24岁）。选择了在TR和速释（IR）之间有选择的抗抑郁药。基于安德森卫生服务利用模型确定了与用药复杂性和可负担性相关的因素。在控制MEPS复杂调查抽样的同时，使用多元逻辑回归检验研究假设。共有625名患有抑郁症的在职成年人约60%的时间使用TR制剂开具处方。与用药可负担性和复杂性相关的因素与使用TR抗抑郁制剂的程度显著相关。确定与使用TR制剂相关的因素将有助于改善抗抑郁药物治疗的可及性和依从性。
