Cao Y, Li A, Li L, Yan X, Fa Y, Zeng L, Fan J, Liu B, Sun Z
Laboratory Animal Center, The Academy of Military Medical Science, Beijing, China; College of Life Sciences, Tarim University, Alaer, China.
Tissue Antigens. 2014 Sep;84(3):304-7. doi: 10.1111/tan.12389. Epub 2014 Jun 5.
The African green monkey may be an ideal replacement for the rhesus monkey in biomedical research, but relatively little is known about the genetic background of major histocompatibility complex (MHC) class I molecules. In analysis of 12 African green monkeys, 13 Chae-A and 19 Chae-B alleles were identified. Among these alleles, 12 Chae-A and 9 Chae-B were new lineages. The full amino acid length deduced for Chae-A genes is 365 amino acids, but for Chae-B genes, the lengths are 365, 362, 361, and 359 amino acids, respectively. There were 1-3 Chae-A alleles and 2-5 Chae-B alleles in each animal. In African green monkeys, rhesus monkeys, and cynomolgus monkeys, the MHC-A and MHC-B alleles display trans-species polymorphism, rather than being clustered in a species-specific fashion.
非洲绿猴可能是生物医学研究中恒河猴的理想替代者，但对于主要组织相容性复合体（MHC）I类分子的遗传背景了解相对较少。在对12只非洲绿猴的分析中，鉴定出了13个Chae - A和19个Chae - B等位基因。在这些等位基因中，12个Chae - A和9个Chae - B是新谱系。Chae - A基因推导的完整氨基酸长度为365个氨基酸，但Chae - B基因的长度分别为365、362、361和359个氨基酸。每只动物中有1 - 3个Chae - A等位基因和2 - 5个Chae - B等位基因。在非洲绿猴、恒河猴和食蟹猴中，MHC - A和MHC - B等位基因表现出跨物种多态性，而不是以物种特异性方式聚集。
