血细胞减少症的挑战世界：鉴别骨髓增生异常综合征与其他骨髓衰竭性疾病。
The challenging world of cytopenias: distinguishing myelodysplastic syndromes from other disorders of marrow failure.
机构信息
The Sidney Kimmel Comprehensive Cancer Center and Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Leukemia Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
The Sidney Kimmel Comprehensive Cancer Center and Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Leukemia Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.
出版信息
Oncologist. 2014 Jul;19(7):735-45. doi: 10.1634/theoncologist.2014-0056. Epub 2014 Jun 4.
Abstract
Over the past decade, our understanding of bone marrow failure has advanced considerably. Marrow failure encompasses multiple overlapping diseases, and there is increasing availability of diagnostic tools to distinguish among the subtypes. Identification of genetic alterations that underlie marrow failure has also greatly expanded, especially for myelodysplastic syndromes. Molecular markers are increasingly used to guide the management of myelodysplasia and may distinguish this diagnosis from other marrow failure disorders. This review summarizes the current state of distinguishing among causes of marrow failure and discusses the potential uses of multiple diagnostic and prognostic indicators in the management of myelodysplastic syndromes and other bone marrow failure disorders.
摘要
在过去的十年中，我们对骨髓衰竭的理解有了很大的进展。骨髓衰竭包括多种重叠的疾病，并且有越来越多的诊断工具可用于区分亚型。导致骨髓衰竭的遗传改变的识别也大大扩展了，尤其是对于骨髓增生异常综合征。分子标志物越来越多地用于指导骨髓增生异常的治疗，并且可以将该诊断与其他骨髓衰竭疾病区分开来。这篇综述总结了目前区分骨髓衰竭原因的状态，并讨论了多种诊断和预后指标在骨髓增生异常综合征和其他骨髓衰竭疾病的治疗中的潜在用途。
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