Department of Internal Medicine, New York University Grossman School of Medicine, 240 East 38th street, 19th Floor, New York, NY, 10016, USA.
Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
J Med Case Rep. 2022 Jun 8;16(1):227. doi: 10.1186/s13256-022-03447-y.
Large granular lymphocytic leukemia is a rare lymphocytic neoplasm that can pose a treatment challenge in patients with severe neutropenia in whom conventional therapies fail. We report one of the first cases in which allogeneic stem cell therapy was used as treatment for large granular lymphocytic leukemia. We report and discuss the case of a 42-year-old white Caucasian female who, despite multiple therapies including methotrexate, cyclophosphamide, prednisone, cyclosporine, and pentostatin, continued to show severe neutropenia and recurrent infections. The patient was treated successfully and cured by allogeneic stem cell transplant without any major complications.
The significant importance of this case report is the introduction of a new treatment algorithm for challenging cases of T-cell large granular lymphocytic leukemia in which standard care fails. We hope that this case report will raise awareness of the potential benefits of allogeneic stem cell transplant in the treatment of aggressive forms of T-cell large granular lymphocytic leukemia.
大颗粒淋巴细胞白血病是一种罕见的淋巴细胞肿瘤，如果常规治疗失败，且患者中性粒细胞严重减少，可能会带来治疗挑战。我们报告首例使用异基因干细胞治疗大颗粒淋巴细胞白血病的病例。我们报告并讨论了一名 42 岁的白人女性病例，尽管接受了多种治疗，包括甲氨蝶呤、环磷酰胺、泼尼松、环孢素和喷司他丁，但她仍持续出现严重中性粒细胞减少和反复感染。该患者通过异基因干细胞移植成功治疗并治愈，无任何重大并发症。
本病例报告的重要意义在于为标准治疗失败的 T 细胞大颗粒淋巴细胞白血病的疑难病例引入了新的治疗方案。我们希望本病例报告将提高人们对异基因干细胞移植在治疗侵袭性 T 细胞大颗粒淋巴细胞白血病方面的潜在益处的认识。
