Makis William, Rakheja Rajan, Lavoie Josee, Hickeson Marc
Department of Nuclear Medicine, Brandon Regional Health Centre, 150 McTavish Ave E, Brandon, MB R7A 2B3 Canada.
Department of Nuclear Medicine, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Ave West, M2, Montreal, QC H3A 1A1 Canada.
Nucl Med Mol Imaging. 2012 Jun;46(2):119-24. doi: 10.1007/s13139-012-0128-x. Epub 2012 Feb 14.
Tetrasomy 8 is a relatively rare chromosomal abnormality that has been reported in only 33 cases in hematologic disorders. It is known for its association with aggressive acute myeloid leukemia (AML) and myeloid sarcoma and is considered a very poor prognostic factor. Myeloid sarcoma is a rare hematologic malignancy characterized by tumor masses consisting of immature myeloid cells, presenting at an extramedullary site. We present a case of a 17-year-old boy referred for an (18)F-FDG PET/CT for the evaluation of pleural masses and spinal bone lesions seen on CT, after presenting with a 4 month history of chest pain. The PET/CT revealed extensive FDG-avid extramedullary disease in the soft tissues of the chest, abdomen, and pelvis, which were biopsy-proven to be myeloid sarcoma, as well as extensive intramedullary disease biopsy proven to be AML. This is the first report of the use of (18)F-FDG PET/CT to stage a subset of aggressive AML and myeloid sarcoma in a patient with an associated chromosomal abnormality (tetrasomy 8).
8号染色体四体是一种相对罕见的染色体异常，在血液系统疾病中仅报道过33例。它因与侵袭性急性髓系白血病（AML）和髓系肉瘤相关而闻名，被认为是一个非常差的预后因素。髓系肉瘤是一种罕见的血液系统恶性肿瘤，其特征是肿瘤肿块由未成熟髓系细胞组成，出现在髓外部位。我们报告一例17岁男孩，因胸痛4个月后，接受（18）F-FDG PET/CT检查，以评估CT上所见的胸膜肿块和脊柱骨病变。PET/CT显示胸部、腹部和骨盆软组织中广泛的FDG摄取增加的髓外病变，活检证实为髓系肉瘤，以及广泛的骨髓内病变，活检证实为AML。这是首例关于使用（18）F-FDG PET/CT对一名伴有染色体异常（8号染色体四体）的侵袭性AML和髓系肉瘤患者进行分期的报告。
