Kim Woo Hyoung, Kim Chang Guhn, Kim Dae-Weung
Department of Nuclear Medicine, Wonkwang University School of Medicine, 344-2 Shinyong-Dong, Iksan, Korea.
Department of Nuclear Medicine, Wonkwang University School of Medicine, 344-2 Shinyong-Dong, Iksan, Korea ; Institute of Wonkwang Medical Science, 344-2 Shinyong-Dong, Iksan, Korea.
Nucl Med Mol Imaging. 2012 Sep;46(3):182-8. doi: 10.1007/s13139-012-0146-8. Epub 2012 Jun 21.
Standardized uptake values (SUVs) normalized by lean body mass (LBM) determined by CT were compared with those normalized by LBM estimated using predictive equations (PEs) in normal liver, spleen, and aorta using (18)F-FDG PET/CT.
Fluorine-18 fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) was conducted on 453 patients. LBM determined by CT was defined in 3 ways (LBMCT1-3). Five PEs were used for comparison (LBMPE1-5). Tissue SUV normalized by LBM (SUL) was calculated using LBM from each method (SULCT1-3, SULPE1-5). Agreement between methods was assessed by Bland-Altman analysis. Percentage difference and percentage error were also calculated.
For all liver SULCTs vs. liver SULPEs except liver SULPE3, the range of biases, SDs of percentage difference and percentage errors were -0.17-0.24 SUL, 6.15-10.17 %, and 25.07- 38.91 %, respectively. For liver SULCTs vs. liver SULPE3, the corresponding figures were 0.47-0.69 SUL, 10.90-11.25 %, and 50.85-51.55 %, respectively, showing the largest percentage errors and positive biases. Irrespective of magnitudes of the biases, large percentage errors of 25.07-51.55 % were observed between liver SULCT1-3 and liver SULPE1-5. The results of spleen and aorta SULCTs and SULPEs comparison were almost identical to those for liver.
The present study demonstrated substantial errors in individual SULPEs compared with SULCTs as a reference value. Normalization of SUV by LBM determined by CT rather than PEs may be a useful approach to reduce errors in individual SULPEs.
使用（18）F-FDG PET/CT，比较通过CT测定的瘦体重（LBM）标准化的标准化摄取值（SUV）与使用预测方程（PE）估算的LBM标准化的SUV在正常肝脏、脾脏和主动脉中的情况。
对453例患者进行氟-18氟脱氧葡萄糖（F-FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）。通过CT测定的LBM以3种方式定义（LBMCT1-3）。使用5种PE进行比较（LBMPE1-5）。使用每种方法的LBM计算通过LBM标准化的组织SUV（SUL）（SULCT1-3，SULPE1-5）。通过Bland-Altman分析评估方法之间的一致性。还计算了百分比差异和百分比误差。
对于除肝脏SULPE3之外的所有肝脏SULCT与肝脏SULPE，偏差范围、百分比差异的标准差和百分比误差分别为-0.17至0.24 SUL、6.15至10.17%和25.07至38.91%。对于肝脏SULCT与肝脏SULPE3，相应数字分别为0.47至0.69 SUL、10.90至11.25%和50.85至51.55%，显示出最大的百分比误差和正偏差。无论偏差大小如何，在肝脏SULCT1-3和肝脏SULPE1-5之间观察到25.07至51.55%的大百分比误差。脾脏和主动脉SULCT与SULPE比较的结果与肝脏的结果几乎相同。
本研究表明，与作为参考值的SULCT相比，个体SULPE存在大量误差。通过CT而非PE测定的LBM对SUV进行标准化可能是减少个体SULPE误差的有用方法。
