Narita Atsushi, Shiomi Susumu, Katayama Yutaka, Yamanaga Takashi, Daisaki Hiromitsu, Hamada Kazuo, Watanabe Yasuyoshi
Department of Physiology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
Imaging Information Technology Center, Nihon Medi-Physics Co., Ltd., Amagasaki Front Building 4F, 1-2-6 Shioe, Amagasaki, Hyogo, 661-0976, Japan.
Radiol Phys Technol. 2016 Jul;9(2):170-7. doi: 10.1007/s12194-016-0346-5. Epub 2016 Feb 12.
Our aim in this study was to verify the usefulness of the standardized uptake value (SUV) normalized by individual CT-based lean body mass (LBMCT) in application of PET response criteria in solid tumors (PERCIST).We retrospectively investigated 14 patients (4 male and 10 female) with malignant lymphoma who were undergoing chemotherapy. (18)F-FDG PET/CT examinations were performed before and after chemotherapy. The LBMCT was calculated by estimation of fat weight from CT data (from skull base to pelvis). The mean ± standard deviation (SD) and the Bland-Altman plot were used for comparison among body weight, LBMCT, and LBM derived from a predictive equation (LBMPE). Indices for FDG uptake in the liver were: SUV, SUV based on LBMPE (SULPE), and SUV based on LBMCT (SULCT). Overall differences between the uptake values were analyzed by one-way ANOVA. If the ANOVA showed significance, differences between uptake values were investigated further by use of the Tukey-Kramer test. The mean values of body weight, LBMPE, and LBMCT were: 55.4 ± 14.9 (39.0-112.0), 43.0 ± 10.5 (31.3-75.2), and 35.3 ± 9.8 (23.4-75.8) kg, respectively. There was a wide dispersion between LBMPE and LBMCT (differences, 7.6 ± 3.6 kg; 95 % CI, 6.42-8.85). LBMPE was higher than LBMCT in all the cases except in Case 11. The mean uptake values significantly differed among SUV, SULPE, and SULCT (F = 68.3, p < 0.05). Whereas SULPE deviated from PERCIST criteria in seven patients, SULCT satisfied the criteria except in one case. These results suggest that liver SULCT is useful for application of PERCIST.
本研究的目的是验证基于个体CT的瘦体重（LBMCT）标准化后的标准化摄取值（SUV）在实体瘤PET反应标准（PERCIST）应用中的有效性。我们回顾性研究了14例正在接受化疗的恶性淋巴瘤患者（4例男性和10例女性）。在化疗前后进行了（18）F-FDG PET/CT检查。通过从CT数据（从颅底到骨盆）估算脂肪重量来计算LBMCT。使用平均值±标准差（SD）和Bland-Altman图对体重、LBMCT和根据预测方程得出的瘦体重（LBMPE）进行比较。肝脏FDG摄取的指标为：SUV、基于LBMPE的SUV（SULPE）和基于LBMCT的SUV（SULCT）。摄取值之间的总体差异通过单因素方差分析进行分析。如果方差分析显示有显著性差异，则使用Tukey-Kramer检验进一步研究摄取值之间的差异。体重、LBMPE和LBMCT的平均值分别为：55.4±14.9（39.0 - 112.0）、43.0±10.5（31.3 - 75.2）和35.3±9.8（23.4 - 75.8）kg。LBMPE和LBMCT之间存在较大差异（差异为7.6±3.6 kg；95%CI，6.42 - 8.85）。除病例11外，所有病例中LBMPE均高于LBMCT。SUV、SULPE和SULCT之间的平均摄取值有显著差异（F = 68.3，p < 0.05）。虽然7例患者的SULPE偏离了PERCIST标准，但除1例病例外，SULCT均符合标准。这些结果表明肝脏SULCT对PERCIST的应用是有用的。
