Kim Yong-Il, Im Hyung-Jun, Paeng Jin Chul, Lee Jae Sung, Eo Jae Seon, Kim Dong Hyun, Kim Euishin E, Kang Keon Wook, Chung June-Key, Lee Dong Soo
Department of Nuclear Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744 South Korea ; Department of Molecular Medicine and Biopharmaceutical Sciences, WCU Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.
Department of Nuclear Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744 South Korea.
Nucl Med Mol Imaging. 2012 Dec;46(4):254-60. doi: 10.1007/s13139-012-0159-3. Epub 2012 Aug 2.
(18)F-FP-CIT positron emission tomography (PET) is an effective imaging for dopamine transporters. In usual clinical practice, (18)F-FP-CIT PET is analyzed visually or quantified using manual delineation of a volume of interest (VOI) for the striatum. In this study, we suggested and validated two simple quantitative methods based on automatic VOI delineation using statistical probabilistic anatomical mapping (SPAM) and isocontour margin setting.
Seventy-five (18)F-FP-CIT PET images acquired in routine clinical practice were used for this study. A study-specific image template was made and the subject images were normalized to the template. Afterwards, uptakes in the striatal regions and cerebellum were quantified using probabilistic VOI based on SPAM. A quantitative parameter, QSPAM, was calculated to simulate binding potential. Additionally, the functional volume of each striatal region and its uptake were measured in automatically delineated VOI using isocontour margin setting. Uptake-volume product (QUVP) was calculated for each striatal region. QSPAM and QUVP were compared with visual grading and the influence of cerebral atrophy on the measurements was tested.
Image analyses were successful in all the cases. Both the QSPAM and QUVP were significantly different according to visual grading (P < 0.001). The agreements of QUVP or QSPAM with visual grading were slight to fair for the caudate nucleus (κ = 0.421 and 0.291, respectively) and good to perfect to the putamen (κ = 0.663 and 0.607, respectively). Also, QSPAM and QUVP had a significant correlation with each other (P < 0.001). Cerebral atrophy made a significant difference in QSPAM and QUVP of the caudate nuclei regions with decreased (18)F-FP-CIT uptake.
Simple quantitative measurements of QSPAM and QUVP showed acceptable agreement with visual grading. Although QSPAM in some group may be influenced by cerebral atrophy, these simple methods are expected to be effective in the quantitative analysis of (18)F-FP-CIT PET in usual clinical practice.
（18）F - FP - CIT正电子发射断层扫描（PET）是一种用于多巴胺转运体的有效成像方法。在常规临床实践中，（18）F - FP - CIT PET通过对纹状体感兴趣区（VOI）进行手动勾勒来进行视觉分析或定量分析。在本研究中，我们提出并验证了两种基于自动VOI勾勒的简单定量方法，即使用统计概率解剖图谱（SPAM）和等轮廓边缘设置。
本研究使用了在常规临床实践中获取的75幅（18）F - FP - CIT PET图像。制作了特定研究的图像模板，并将受试者图像归一化到该模板。之后，使用基于SPAM的概率VOI对纹状体区域和小脑的摄取进行定量。计算一个定量参数QSPAM以模拟结合潜能。此外，使用等轮廓边缘设置在自动勾勒的VOI中测量每个纹状体区域的功能体积及其摄取量。计算每个纹状体区域的摄取 - 体积乘积（QUVP）。将QSPAM和QUVP与视觉分级进行比较，并测试脑萎缩对测量结果的影响。
所有病例的图像分析均成功。QSPAM和QUVP根据视觉分级均有显著差异（P < 0.001）。QUVP或QSPAM与视觉分级的一致性对于尾状核来说为轻度到中度（κ分别为0.421和0.291），对于壳核来说为良好到极佳（κ分别为0.663和0.607）。此外，QSPAM和QUVP彼此之间有显著相关性（P < 0.001）。脑萎缩使（18）F - FP - CIT摄取降低的尾状核区域的QSPAM和QUVP有显著差异。
QSPAM和QUVP的简单定量测量与视觉分级显示出可接受的一致性。虽然某些组中的QSPAM可能受脑萎缩影响，但这些简单方法有望在常规临床实践中对（18）F - FP - CIT PET的定量分析中有效。
