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本文引用的文献

1
Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.铁载体偶联单碳青霉烯类化合物对临床相关铜绿假单胞菌的有效性的结构基础。
Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22002-7. doi: 10.1073/pnas.1013092107. Epub 2010 Dec 6.
2
Chemistry and biology of siderophores.铁载体的化学与生物学。
Nat Prod Rep. 2010 May;27(5):637-57. doi: 10.1039/b906679a.
3
Iron uptake and metabolism in pseudomonads.假单胞菌中铁的摄取和代谢。
Appl Microbiol Biotechnol. 2010 May;86(6):1637-45. doi: 10.1007/s00253-010-2550-2. Epub 2010 Mar 30.
4
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.BAL30072 是一种新型的含磺胺的铁载体，对多重耐药革兰氏阴性杆菌具有活性。体外研究结果表明。
Antimicrob Agents Chemother. 2010 Jun;54(6):2291-302. doi: 10.1128/AAC.01525-09. Epub 2010 Mar 22.
5
Treatment options for multidrug-resistant nonfermenters.多重耐药非发酵菌的治疗选择。
Expert Rev Anti Infect Ther. 2010 Mar;8(3):303-15. doi: 10.1586/eri.09.125.
6
Multidrug-resistant Gram-negative infections: what are the treatment options?多重耐药革兰氏阴性菌感染：有哪些治疗选择？
Drugs. 2009 Oct 1;69(14):1879-901. doi: 10.2165/11315690-000000000-00000.
7
Siderophores as drug delivery agents: application of the "Trojan Horse" strategy.铁载体作为药物递送剂：“特洛伊木马”策略的应用。
Biometals. 2009 Aug;22(4):615-24. doi: 10.1007/s10534-009-9219-2. Epub 2009 Feb 12.
8
Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America.有害病菌，无药可医：谨防“ESKAPE”！美国传染病学会的最新报告
Clin Infect Dis. 2009 Jan 1;48(1):1-12. doi: 10.1086/595011.
9
The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America.抗生素耐药性感染的流行：美国传染病学会向医学界发出的行动呼吁。
Clin Infect Dis. 2008 Jan 15;46(2):155-64. doi: 10.1086/524891.
10
The efficiency of C-4 substituents in activating the beta-lactam scaffold towards serine proteases and hydroxide ion.C-4取代基在激活β-内酰胺骨架以作用于丝氨酸蛋白酶和氢氧根离子方面的效率。
Org Biomol Chem. 2007 Aug 21;5(16):2617-26. doi: 10.1039/b706622h.

新型铁载体共轭单氨基二醇的制备、革兰氏阴性抗菌活性及水解稳定性

Preparation, gram-negative antibacterial activity, and hydrolytic stability of novel siderophore-conjugated monocarbam diols.

作者信息

Flanagan Mark E, Brickner Steven J, Lall Manjinder, Casavant Jeffrey, Deschenes Laura, Finegan Steven M, George David M, Granskog Karl, Hardink Joel R, Huband Michael D, Hoang Thuy, Lamb Lucinda, Marra Andrea, Mitton-Fry Mark, Mueller John P, Mullins Lisa M, Noe Mark C, O'Donnell John P, Pattavina David, Penzien Joseph B, Schuff Brandon P, Sun Jianmin, Whipple David A, Young Jennifer, Gootz Thomas D

机构信息

Worldwide Medicinal Chemistry, Pharmaceutical Sciences, Antibacterials Research Unit, and Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development , Eastern Point Road, Groton, Connecticut 06340, United States.

SJ Brickner Consulting, LLC, Ledyard, Connecticut 06339, United States.

出版信息

ACS Med Chem Lett. 2011 Mar 2;2(5):385-90. doi: 10.1021/ml200012f. eCollection 2011 May 12.

DOI:10.1021/ml200012f
PMID:24900319
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4018130/
Abstract

A novel series of monocarbam compounds exhibiting promising antibacterial activity against multidrug resistant Gram-negative microorganisms is reported, along with the synthesis of one such molecule MC-1 (1). Also reported are structure-activity relationships associated with the in vitro and in vivo efficacy of 1 and related analogues in addition to the hydrolytic stability of such compounds and possible implications thereof.

摘要

报道了一系列新型单氨基甲酸盐化合物，它们对多重耐药革兰氏阴性微生物具有有前景的抗菌活性，同时还报道了其中一种分子MC-1（1）的合成。除了此类化合物的水解稳定性及其可能的影响外，还报道了与1及相关类似物的体外和体内疗效相关的构效关系。