一种抑制线粒体内氧化还原应激的策略。
A Strategy for Suppressing Redox Stress within Mitochondria.
作者信息
Arce Pablo M, Khdour Omar M, Goldschmidt Ruth, Armstrong Jeffrey S, Hecht Sidney M
机构信息
Center for BioEnergetics, Biodesign Institute, and Department of Chemistry and Biochemistry, Arizona State University , 1001 South McAllister Avenue, Tempe, Arizona 85287, United States.
出版信息
ACS Med Chem Lett. 2011 May 31;2(8):608-13. doi: 10.1021/ml200095w. eCollection 2011 Aug 11.
An aza analogue (1) of the experimental neuroprotective drug idebenone has been prepared and evaluated. The compound quenches lipid peroxidation more effectively than α-tocopherol and potently suppresses reactive oxygen species in cells under oxidative stress. It is thought to do so via a catalytic cycle in which both forms of oxidative stress are suppressed simultaneously. Consequently, the compound effectively protects cultured CEM leukemia cells and Friedreich's ataxia fibroblasts from oxidative stress more effectively than idebenone or idebenol.
一种实验性神经保护药物艾地苯醌的氮杂类似物（1）已被制备并评估。该化合物比α-生育酚更有效地淬灭脂质过氧化，并在氧化应激下有效抑制细胞中的活性氧。据认为，它是通过一个催化循环来实现的，在这个循环中，两种形式的氧化应激同时受到抑制。因此，该化合物比艾地苯醌或艾地醇更有效地保护培养的CEM白血病细胞和弗里德赖希共济失调成纤维细胞免受氧化应激。
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