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学术环境中的药物研发:发挥自身优势。

Drug discovery in an academic setting: playing to the strengths.

作者信息

Huryn Donna M

机构信息

Department of Pharmaceutical Sciences, University of Pittsburgh , 712 Salk Hall, 3501 Terrace Street, Pittsburgh, Pennsylvania 15261, United States.

出版信息

ACS Med Chem Lett. 2013 Jan 17;4(3):313-5. doi: 10.1021/ml400012g. eCollection 2013 Mar 14.

Abstract

Drug discovery and medicinal chemistry initiatives in academia provide an opportunity to create a unique environment that is distinct from the traditional industrial model. Two characteristics of a university setting that are not usually associated with pharma are the ability to pursue high-risk projects and a depth of expertise, infrastructure, and capabilities in focused areas. Encouraging, supporting, and fostering drug discovery efforts that take advantage of these and other distinguishing characteristics of an academic setting can lead to novel and innovative therapies that might not be discovered otherwise.

摘要

学术界的药物研发和药物化学项目提供了一个机会,来创建一个有别于传统产业模式的独特环境。大学环境的两个通常与制药行业无关的特点是能够开展高风险项目,以及在特定领域拥有深厚的专业知识、基础设施和能力。鼓励、支持并促进利用学术环境的这些及其他显著特征的药物研发工作,可能会带来否则可能无法发现的新颖创新疗法。

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本文引用的文献

1
Future horizons in drug discovery research.
ACS Med Chem Lett. 2012 Jan 20;3(2):80-2. doi: 10.1021/ml3000116. eCollection 2012 Feb 9.
2
Challenges for academic drug discovery.
Angew Chem Int Ed Engl. 2012 Nov 19;51(47):11680-4. doi: 10.1002/anie.201204625. Epub 2012 Oct 24.
3
Growing PAINS in academic drug discovery.
Future Med Chem. 2011 May;3(7):797-801. doi: 10.4155/fmc.11.44.
4
US academic drug discovery.
Nat Rev Drug Discov. 2011 Jun;10(6):409-10. doi: 10.1038/nrd3462.
5
Observations on screening-based research and some concerning trends in the literature.
Future Med Chem. 2010 Oct;2(10):1529-46. doi: 10.4155/fmc.10.237.

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