Skin Research Center, Department of Dermatology, Shahid Beheshti University of Medical Sciences, Shohada-e-Tajrish Hospital, Shahrdari Street, Tehran 1989934148, Iran.
Biomed Res Int. 2014;2014:853705. doi: 10.1155/2014/853705. Epub 2014 May 12.
Pemphigus is an autoimmune blistering disease mediated by autoantibodies directed against keratinocyte adhesion molecules. Leptin, an adipocyte-derived hormone, plays a role in immune responses and promotes autoimmunity.
This study was conducted to determine whether serum leptin levels are altered in pemphigus patients and whether there is any correlation between leptin levels and the severity of disease.
This study included 47 newly diagnosed patients with pemphigus and 43 age- and sex-matched healthy controls. Clinical characteristics and pemphigus area and activity score (PAAS) were assessed. Serum leptin levels (ng/mL) were measured by a commercial enzyme-linked immunosorbent assay (ELISA).
Patients did not differ significantly in serum leptin levels from healthy controls (median (range): 10.8 (0.1-110) ng/mL versus 12 (0.5-69.9) ng/mL and P = 0.53). There was no significant association between serum leptin concentrations and severity of disease measured by PAAS (r s = 0.06, P = 0.70).
The results suggest that pemphigus does not have a direct influence on serum leptin levels and the pathogenesis of pemphigus seems to be not dependent on the connection with adipose tissue.
天疱疮是一种自身免疫性水疱病，由针对角质形成细胞黏附分子的自身抗体介导。瘦素是一种脂肪细胞衍生的激素，在免疫反应中发挥作用，并促进自身免疫。
本研究旨在确定天疱疮患者的血清瘦素水平是否发生改变，以及瘦素水平与疾病严重程度之间是否存在相关性。
本研究纳入了 47 例新诊断的天疱疮患者和 43 名年龄和性别匹配的健康对照者。评估了临床特征和天疱疮面积和活动评分（PAAS）。采用商业酶联免疫吸附试验（ELISA）测量血清瘦素水平（ng/mL）。
患者的血清瘦素水平与健康对照组相比无显著差异（中位数（范围）：10.8（0.1-110）ng/mL 与 12（0.5-69.9）ng/mL，P=0.53）。PAAS 测量的疾病严重程度与血清瘦素浓度之间无显著相关性（r s=0.06，P=0.70）。
这些结果表明，天疱疮对血清瘦素水平没有直接影响，天疱疮的发病机制似乎与脂肪组织无关。
