Aly Dalia G, Abdallah Ihab Y, Hanafy Noha S, Elsaie Mohamed L, Hafiz Neveen A A
Department of Dermatology and Venereology, National Research Center, Giza, Egypt.
J Drugs Dermatol. 2013 Feb;12(2):e25-9.
Leptin, an adipocyte-derived hormone, has been shown to have several immunological effects similar to those of proinflammatory cytokines. The relationship between serum leptin, psoriasis, and obesity is still conflicted, and very few studies have investigated its role in skin diseases other than psoriasis.
To evaluate the possible relationship between serum leptin in nonobese patients with psoriasis and other randomly selected skin diseases.
Eighty subjects (40 patients with psoriasis, 20 patients with other randomly selected skin diseases, and 20 healthy controls) were included in the study. Fasting serum leptin levels of the study groups were examined by sandwich enzyme-linked immunosorbent assay.
Elevated serum leptin levels were detected in both nonobese patients with psoriasis (P=.004) and those with other randomly selected skin diseases (P=.05). Leptin levels failed to correlate to the Psoriasis Area and Severity Index score of psoriatic patients. Both sexes demonstrated comparable levels of serum leptin in psoriatic patients, while female patients suffering from other skin diseases showed higher levels of serum leptin than did males of the same group.
Leptin may play a role in the immunopathogenesis of psoriasis and other skin diseases, even in the absence of obesity as a cofactor.
瘦素是一种由脂肪细胞分泌的激素，已被证明具有多种与促炎细胞因子类似的免疫作用。血清瘦素、银屑病和肥胖之间的关系仍存在争议，并且很少有研究调查其在银屑病以外的其他皮肤病中的作用。
评估非肥胖银屑病患者血清瘦素与其他随机选择的皮肤病之间可能存在的关系。
本研究纳入80名受试者（40例银屑病患者、20例其他随机选择的皮肤病患者和20名健康对照）。采用夹心酶联免疫吸附测定法检测研究组的空腹血清瘦素水平。
非肥胖银屑病患者（P = 0.004）和其他随机选择的皮肤病患者（P = 0.05）的血清瘦素水平均升高。瘦素水平与银屑病患者的银屑病面积和严重程度指数评分无关。银屑病患者中，男女血清瘦素水平相当，而患有其他皮肤病的女性患者血清瘦素水平高于同组男性。
即使不存在肥胖这一辅助因素，瘦素可能在银屑病和其他皮肤病的免疫发病机制中起作用。
