HLA 相关性与 T 细胞介导的药物超敏反应的临床意义：最新综述。
HLA associations and clinical implications in T-cell mediated drug hypersensitivity reactions: an updated review.
机构信息
Department of Pharmacy Administration, Chang Gung Memorial Hospital, Linkou 33305, Taiwan.
Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospitals, Linkou 33305, Taiwan.
出版信息
J Immunol Res. 2014;2014:565320. doi: 10.1155/2014/565320. Epub 2014 May 8.
Abstract
T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the most life-threatening severe cutaneous adverse reactions (SCARs). Recent advances in pharmacogenetic studies show strong genetic associations between human leukocyte antigen (HLA) alleles and susceptibility to drug hypersensitivity. This review summarizes the literature on recent progresses in pharmacogenetic studies and clinical application of pharmacogenetic screening based on associations between SCARs and specific HLA alleles to avoid serious conditions associated with drug hypersensitivity.
摘要
T 细胞介导的药物过敏反应范围从轻度皮疹到严重致命反应不等。其中，药物反应伴嗜酸性粒细胞增多和全身症状（DRESS）或药物诱导的超敏反应综合征（DIHS）、史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症（SJS/TEN）等是一些最具威胁生命的严重皮肤不良反应（SCARs）。最近的药物遗传学研究进展表明，人类白细胞抗原（HLA）等位基因与药物过敏易感性之间存在强烈的遗传关联。本文综述了基于 SCARs 与特定 HLA 等位基因之间的关联的药物遗传学研究和药物遗传学筛查的临床应用的最新进展，以避免与药物过敏相关的严重情况。
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