Yeniova Abdullah Ozgür, Küçükazman Metin, Ata Naim, Dal Kürşat, Kefeli Ayşe, Başyiğit Sebahat, Aktaş Bora, Ağladioğlu Kadir, Akin Kadir Okhan, Ertugrul Derun Taner, Nazligül Yaşar, Beyan Esin
Hepatogastroenterology. 2014 Mar-Apr;61(130):422-5.
BACKGROUND/AIMS: Non-alcoholic fatty liver disease (NAFLD) is a clinical term that covers simple fatty liver (SFL) and non-alcoholic steatohepatitis (NASH), and high-sensitivity C-reactive protein (hs-CRP) is a marker of inflammation. The aim of the present study was to investigate the relationship between steatosis and hs-CRP in patients with ultrasonographically verified NAFLD.
We examined 296 consecutive patients. NAFLD was detected by ultrasound (US). Patients with NAFLD who had an alanine aminotransferase (ALT) level of > 40 IU/mL were considered to have NASH and those with normal liver function test results were considered to have SFL. Patients who did not have NAFLD constituted the control group. The SFL, NASH and control groups were compared in terms of hs-CRP levels.
Of 296 patients, 86 had normal hepatic US findings and 210 had hepatosteatosis. Hs-CRP levels were higher in patients with NAFLD as compared to the control group (0.68 mg/ dL vs. 0.34 mg/dL, respectively; P < 0.05). There was no significant difference between patients with SFL and NASH in terms of hs-CRP levels (P > 0.05). Logistic regression analysis revealed that hs-CRP was a strong predictor of NAFLD (odds ratio: 6.04; 95% confidence interval: 2.08-17.74).
hs-CRP can be used as a non-invasive marker of NAFLD as it was found to be a strong predictor of NAFLD in this study.
背景/目的：非酒精性脂肪性肝病（NAFLD）是一个涵盖单纯性脂肪肝（SFL）和非酒精性脂肪性肝炎（NASH）的临床术语，而高敏C反应蛋白（hs-CRP）是炎症的一个标志物。本研究的目的是调查经超声检查证实的NAFLD患者中脂肪变性与hs-CRP之间的关系。
我们检查了296例连续患者。通过超声（US）检测NAFLD。丙氨酸氨基转移酶（ALT）水平>40 IU/mL的NAFLD患者被认为患有NASH，肝功能检查结果正常的患者被认为患有SFL。没有NAFLD的患者构成对照组。比较SFL、NASH和对照组的hs-CRP水平。
在296例患者中，86例肝脏超声检查结果正常，210例有肝脂肪变性。与对照组相比，NAFLD患者的hs-CRP水平更高（分别为0.68 mg/dL和0.34 mg/dL；P<0.05）。SFL和NASH患者之间的hs-CRP水平无显著差异（P>0.05）。逻辑回归分析显示，hs-CRP是NAFLD的一个强有力的预测指标（优势比：6.04；95%置信区间：2.08-17.74）。
在本研究中，hs-CRP被发现是NAFLD的一个强有力的预测指标，因此可作为NAFLD的一种非侵入性标志物。
