Center for Catalytic Hydrocarbon Functionalizations, Institute of Basic Science (IBS) , Daejeon 305-701, Korea.
Org Lett. 2014 Jun 20;16(12):3328-31. doi: 10.1021/ol501338h. Epub 2014 Jun 5.
N-Substituted hydroxylamines such as aroyloxy- or acyloxycarbamates were successfully employed as synthetically versatile amino precursors in the iridium-catalyzed direct C-H amidation of arenes. The reaction proceeds smoothly at room temperature over a broad range of substrates with high functional group tolerance to afford N-substituted arylamine products.
N-取代羟胺，如芳氧基或酰氧基氨基甲酸酯，在铱催化的芳基直接 C-H 酰胺化反应中被成功用作多功能的氨基前体。该反应在室温下在很宽的底物范围内顺利进行，具有高官能团容忍度，可得到 N-取代的芳基胺产物。
