Qin Qixue, Yu Shouyun
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, China.
Org Lett. 2014 Jul 3;16(13):3504-7. doi: 10.1021/ol501457s. Epub 2014 Jun 25.
A room temperature redox neutral direct C-H amidation of heteroarenes has been achieved. Hydroxylamine derivatives, which are easily accessed, have been employed as tunable nitrogen sources. These reactions were enabled by a visible-light-promoted single-electron transfer pathway without a directing group. A variety of heteroarenes, such as indoles, pyrroles, and furans, could go through this amidation with high yields (up to 98%). These reactions are highly regioselective, and all the products were isolated as a single regioisomer.
已实现室温下杂芳烃的氧化还原中性直接C-H酰胺化反应。易于获取的羟胺衍生物已被用作可调氮源。这些反应通过可见光促进的单电子转移途径实现，无需导向基团。多种杂芳烃，如吲哚、吡咯和呋喃，均可高产率（高达98%）地进行这种酰胺化反应。这些反应具有高度的区域选择性，所有产物均以单一区域异构体形式分离得到。
