Johnson Andrew R, Dilger Jonathan M, Glover Matthew S, Clemmer David E, Carlson Erin E
Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Chem Commun (Camb). 2014 Aug 18;50(64):8849-51. doi: 10.1039/c4cc03257h.
A polyalanine-based peptide which forms a stable, negatively-charged α-helix in the gas phase is reported. Addition of an N-terminal acidic residue forms a stabilizing hydrogen bond network and an electrostatic interaction with the helical dipole. Formation of this secondary structure was demonstrated using ion mobility-mass spectrometry and molecular modelling techniques.
据报道，一种基于聚丙氨酸的肽在气相中形成稳定的带负电荷的α-螺旋。添加一个N端酸性残基会形成一个稳定的氢键网络，并与螺旋偶极产生静电相互作用。利用离子淌度-质谱和分子建模技术证实了这种二级结构的形成。
